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Anti-obesity effects of green tea EGCG, orange peel extract, black tea extract and caffeine in mice fed on a high-fat diet
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TitleInfo
Title
Anti-obesity effects of green tea EGCG, orange peel extract, black tea extract and caffeine in mice fed on a high-fat diet
Name
(type = personal)
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Huang
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Yu-Wen
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Yu-Wen Huang
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author
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CHI-TANG
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Advisory Committee
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CHI-TANG HO
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chair
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HUANG
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QINGRONG
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Advisory Committee
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QINGRONG HUANG
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internal member
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Sang
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Shengmin
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Advisory Committee
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Shengmin Sang
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internal member
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HUANG
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MOU-TUAN
Affiliation
Advisory Committee
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MOU-TUAN HUANG
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outside member
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Rutgers University
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degree grantor
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Graduate School-New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
(qualifier = exact)
2007
DateOther
(qualifier = exact);
(type = degree)
2007
Language
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(authority = ISO 639-3:2007);
(type = text)
English
PhysicalDescription
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electronic
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text/xml
Extent
xii, 81 pages
Abstract
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In this study, we elucidate the anti-obesity effects of EGCG (Epigallocatechin-3-gallate), orange peel extracts (OPE), black tea extracts (BTE), and caffeine (CF) by oral feeding to female CD-1 mice. Female CD-1 mice were fed on high-fat diets containing 0.1% EGCG, 0.2% orange peel extract, 0.2% black tea extract and 0.05% caffeine, singly and in combination for 10 weeks. The body weight gain and weights of abdominal fat and brown adipose tissue were significantly reduced by the diets containing orange peel extract, black tea extract, caffeine, OPE + BTE and OPE + CF. Noticeably, our result also found that mice fed with high-fat diet supplemented daily among the combination of 0.2% OPE + 0.2% BTE + 0.05% CF prevented the body weight gain by 48.8%, the parametrial fat pad weight by 88.2%, retroperitoneal fat pad weight by 82.8% and brown adipose tissue by 63.7% compared to mice fed on high-fat diet. On the basis of these finding, it was supported that oral feeding of orange peel extracts, black tea extracts and caffeine had anti-obesity effects by suppressing body weigh growth and adipose tissue formation. Moreover, it was shown that orange peel extract, black tea extract and caffeine were synergistic in anti-obesity actions.
To clarify the anti-obesity action of orange peel extract, female CD-1 mice were fed on various degrees of orange peel extracts and different composition of orange peel extract for 17 weeks. Our results showed that feeding of different degrees of orange peel extracts to female CD-1 mice fed high-fat diet results in the reduction of body weight, white adipose tissue, brown adipose tissue as well as lipid profile includes total cholesterol, triglyceride, LDL and HDL in blood. Furthermore, long term consumption of dietary orange peel extracts intake considerably decreases diet-induced obesity, hyperglycemia, and hypercholesterolemia in mice without a dose-dependent manner.
To clarify the anti-obesity action of orange peel extract, female CD-1 mice were fed on various degrees of orange peel extracts and different composition of orange peel extract for 17 weeks. Our results showed that feeding of different degrees of orange peel extracts to female CD-1 mice fed high-fat diet results in the reduction of body weight, white adipose tissue, brown adipose tissue as well as lipid profile includes total cholesterol, triglyceride, LDL and HDL in blood. Furthermore, long term consumption of dietary orange peel extracts intake considerably decreases diet-induced obesity, hyperglycemia, and hypercholesterolemia in mice without a dose-dependent manner.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references (p. 74-79).
Subject
(authority = RUETD)
Topic
Food Science
Subject
(authority = ETD-LCSH)
Topic
Weight loss preparations
Subject
(authority = ETD-LCSH)
Topic
Obesity
Subject
(authority = ETD-LCSH)
Topic
Tea
Subject
(authority = ETD-LCSH)
Topic
Green tea
Subject
(authority = ETD-LCSH)
Topic
Diet
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13474
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ETD_207
Identifier
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doi:10.7282/T3SQ90V3
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Name
Yu-Wen Huang
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Copyright holder
Affiliation
Rutgers University. Graduate School-New Brunswick
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Detail
Non-exclusive ETD license
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License
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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