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Weight loss in obese subjects with and without type 2 diabetes treated with the long term appetite suppressant Axokine®
Descriptive
TitleInfo
Title
Weight loss in obese subjects with and without type 2 diabetes treated with the long term appetite suppressant Axokine®
Name
(type = personal)
NamePart
(type = family)
Russell
NamePart
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Tammy L.
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Tammy Russell
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(authority = RUETD)
author
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(type = personal)
NamePart
(type = family)
Shapses
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(type = given)
Susan
Affiliation
Advisory Committee
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Susan Shapses
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(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Watford
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(type = given)
Malcolm
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Advisory Committee
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Malcolm Watford
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(authority = RULIB)
internal member
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(type = personal)
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(type = family)
Hoffman
NamePart
(type = given)
Daniel
Affiliation
Advisory Committee
DisplayForm
Daniel Hoffman
Role
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(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School-New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2007
DateOther
(qualifier = exact);
(type = degree)
2007
Language
LanguageTerm
(authority = ISO 639-3:2007);
(type = text)
English
PhysicalDescription
Form
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electronic
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application/pdf
InternetMediaType
text/xml
Extent
ix, 72 pages
Abstract
(type = abstract)
Studies comparing weight loss between obese or overweight individuals with and without type 2 diabetes show a decreased weight loss in those with type 2 diabetes. The exact mechanisms promoting this discrepancy are unclear but may be related to the type and amount of antidiabetes medication, an altered metabolism, stage of disease, and/or presence of dysphoria. In this study, retrospective weight loss data from two doubleblind, placebo controlled, randomized studies using the long-term appetite suppressant AXOKINE (a modified ciliary neurotrophic factor) were compared. In the first study, a total of 179 obese, nondiabetic subjects received placebo or AXOKINE at a 0.3 µ/kg, 1.0 µg/kg, or 2.0 µ/kg dose for 12 weeks. In the second study, 142 obese subjects with type 2 diabetes received placebo, 0.5 µg/kg or 1.0 µg/kg dose of AXOKINE for 12 weeks.
Nutritional counseling was similar for both groups however the diabetic group received more frequent sessions. Mean weight loss between the two groups was similar with diabetic subjects losing 3.0 ± 2.6 kg vs. 3.4 ± 2.5 kg in the nondiabetic group (1.0 µg/kg dose of AXOKINE). The subjects with diabetes did not have any significant improvements in HbA1c (-0.34 ± 0.89%) or blood sugar levels (-15.5 ± 37.3 mg/dL) from baseline. Diabetic subjects also suffered more from diagnosed co-morbidities (55% of subjects had hypertension and 55% were dyslipidemic) and were likely to be on multiple oral hypoglycemic agents (66% of subjects). The amount of oral hypoglycemic agent did not appear to affect weight loss as those on multiple medications lost a similar amount of weight than the mean weight loss achieved by the nondiabetic subjects (3.3 ± 3.1 kg in the diabetic, multiple medication group vs. 3.4 ± 2.5 kg in the nondiabetic group). In contrast to the hypothesis that diabetic patients would lose less weight with and without AXOKINE compared to nondiabetic counterparts, these results suggest that weight loss is similar over a 12-week time period. A difference in weight loss may have been observed however with a longer study period.
Nutritional counseling was similar for both groups however the diabetic group received more frequent sessions. Mean weight loss between the two groups was similar with diabetic subjects losing 3.0 ± 2.6 kg vs. 3.4 ± 2.5 kg in the nondiabetic group (1.0 µg/kg dose of AXOKINE). The subjects with diabetes did not have any significant improvements in HbA1c (-0.34 ± 0.89%) or blood sugar levels (-15.5 ± 37.3 mg/dL) from baseline. Diabetic subjects also suffered more from diagnosed co-morbidities (55% of subjects had hypertension and 55% were dyslipidemic) and were likely to be on multiple oral hypoglycemic agents (66% of subjects). The amount of oral hypoglycemic agent did not appear to affect weight loss as those on multiple medications lost a similar amount of weight than the mean weight loss achieved by the nondiabetic subjects (3.3 ± 3.1 kg in the diabetic, multiple medication group vs. 3.4 ± 2.5 kg in the nondiabetic group). In contrast to the hypothesis that diabetic patients would lose less weight with and without AXOKINE compared to nondiabetic counterparts, these results suggest that weight loss is similar over a 12-week time period. A difference in weight loss may have been observed however with a longer study period.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references (p. 38-45).
Subject
(authority = RUETD)
Topic
Nutritional Sciences
Subject
(authority = ETD-LCSH)
Topic
Appetite suppressants
Subject
(authority = ETD-LCSH)
Topic
Diabetics
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13721
Identifier
ETD_168
Identifier
(type = doi)
doi:10.7282/T30G3KKQ
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
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Name
Tammy Russell
Role
Copyright holder
Affiliation
Rutgers University. Graduate School-New Brunswick
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Type
Permission or license
Detail
Non-exclusive ETD license
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(AUTHORITY = rulib);
(ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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