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Tea polyphenol (-)epigallocatechin-3-gallate: a new trapping agent for reactive dicarbonyl species
Descriptive
TitleInfo
Title
Tea polyphenol (-)epigallocatechin-3-gallate: a new trapping agent for reactive dicarbonyl species
Name
(type = personal)
NamePart
(type = family)
Shao
NamePart
(type = given)
Xi
DisplayForm
Xi Shao
Role
RoleTerm
(authority = RUETD)
author
Name
(type = personal)
NamePart
(type = family)
Sang
NamePart
(type = given)
Sheng Min
Affiliation
Advisory Committee
DisplayForm
Sheng Min Sang
Role
RoleTerm
(authority = RUETD)
chair
Name
(type = personal)
NamePart
(type = family)
Ho
NamePart
(type = given)
Chi Tang
Affiliation
Advisory Committee
DisplayForm
Chi Tang Ho
Role
RoleTerm
(authority = RUETD)
dissertation committee member
Name
(type = personal)
NamePart
(type = family)
Yang
NamePart
(type = given)
Chung S.
Affiliation
Advisory Committee
DisplayForm
Chung S. Yang
Role
RoleTerm
(authority = RUETD)
outside dissertation committee member
Name
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NamePart
Rutgers University
Role
RoleTerm
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degree grantor
Name
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NamePart
Graduate School-New Brunswick
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
(qualifier = exact)
2007
DateOther
(qualifier = exact);
(type = degree)
2007
Language
LanguageTerm
(authority = ISO 639-3:2007);
(type = text)
English
PhysicalDescription
Form
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electronic
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application/pdf
InternetMediaType
text/xml
Extent
x, 66 pages
Abstract
(type = abstract)
Tea, made from the leaves of Camellia sinensis, is one of the most widely consumed beverages in the world. Many studies in humans, animal models, and cell lines suggest potential health benefits from the consumption of tea, including prevention of cancer, heart disease, and diabetes. The objective of this project is to study the trapping effect of reactive dicarbonyl compounds, the precursors of advanced glycation end products (AGEs), by tea polyphenol epigallocatechin-3-gallate (EGCG), the most abundant and major active component in tea. Previous studies have demonstrated that accumulation of reactive dicarbonyl compounds in human tissue will accelerate the vascular damage in both diabetes and uraemia. In addition, advanced glycation irreversibly and progressively modified proteins over time and yielded the AGEs. AGEs are thought to contribute to the development of diabetes mellitus and its complications. Higher levels of [alpha symbol], [beta symbol]-dicarbonyl compounds (e.g., glyoxal (GO) and methylglyoxal (MGO)) were observed in diabetes patients' plasma than those in healthy people's plasma. Therefore, decreasing the levels of MGO and GO will be a useful approach to prevent the development of diabetic complications. In this study, we found EGCG could trap MGO rapidly under in vitro conditions (pH 7.4 buffer solution, 37 [degree symbol]C) to form carbonyl adducts of EGCG. Two major carbonyl adducts were purified through different column chromatography and identified by 1H, 13C, and 2D NMR and MS analyses. These adducts will serve as standards for our future in vivo studies.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references (p. 61-66).
Subject
(authority = RUETD)
Topic
Food Science
Subject
(authority = ETD-LCSH)
Topic
Camellia oleifera
Subject
(authority = ETD-LCSH)
Topic
Tea
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13722
Identifier
(type = FEDORA_PID)
rutgers-lib:21330
Identifier
ETD_190
Identifier
(type = doi)
doi:10.7282/T3445MZM
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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(AUTHORITY = GS);
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
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(AUTHORITY = rulib);
(ID = 1)
Name
xi shao
Role
Copyright holder
Affiliation
Rutgers University. Graduate School-New Brunswick
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Type
Permission or license
Detail
Non-exclusive ETD license
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(AUTHORITY = rulib);
(ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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application/x-tar
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1656832
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application/x-tar
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