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The physics of chromatin silencing: bi-stability and front propagation
Descriptive
TitleInfo
Title
The physics of chromatin silencing: bi-stability and front propagation
Name
(type = personal)
NamePart
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Sedighi
NamePart
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Mohammad
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Mohammad Sedighi
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author
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(type = family)
Sengupta
NamePart
(type = given)
Anirvan
Affiliation
Advisory Committee
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Anirvan M Sengupta
Role
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chair
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Ruckenstein
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Andrei
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Advisory Committee
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Andrei Ruckenstein
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internal member
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(type = family)
Cheong
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Sang-Wook
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Advisory Committee
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Sang-Wook Cheong
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internal member
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Lukyanov
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Sergei
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Advisory Committee
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Sergei Lukyanov
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internal member
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Mukhopadhyay
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Ranjan
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Advisory Committee
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Ranjan Mukhopadhyay
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outside member
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Rutgers University
Role
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degree grantor
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NamePart
Graduate School-New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
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2007
DateOther
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2007
Language
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(authority = ISO 639-3:2007);
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English
PhysicalDescription
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electronic
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application/pdf
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vi, 80 pages
Abstract
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A mean-field dynamical model of chromatin silencing in budding yeast is provided and the conditions giving rise to two states: one silenced and another un-silenced, is studied. Based on these conditions, the space of control parameters is divided into two distinct regions of mono-stable and bi-stable solutions (the bifurcation diagram). Then, considering both the discrete and continuous versions of the model, the formation of a stable boundary between the silenced and un-silenced areas on DNA is investigated. As a result, a richer phase diagram is provided. The dynamics of the boundary is also studied under different conditions. Consequently, assuming negative feedback due to possible depletion of silencing proteins, the model explains a paradoxical epigenetic behavior of yeast that happens under some mutation. A stochastic treatment of the model is also considered to verify the results of the mean-field approximation and also to understand the role of intrinsic noise at single cell level. This model could be used as a general guide to discuss chromatin silencing in many organisms.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references (p. 77-79).
Subject
(authority = RUETD)
Topic
Physics and Astronomy
Subject
(authority = ETD-LCSH)
Topic
Chromatin
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13726
Identifier
ETD_236
Identifier
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doi:10.7282/T3HD7W3N
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre
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ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Name
Mohammad Sedighi
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Copyright holder
Affiliation
Rutgers University. Graduate School-New Brunswick
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Permission or license
Detail
Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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