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Trapping of methylglyoxal by dietary compounds in vitro

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TitleInfo
Title
Trapping of methylglyoxal by dietary compounds in vitro
Name (type = personal)
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TAN
NamePart (type = given)
DI
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DI TAN
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RoleTerm (authority = RULIB)
author
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HO
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CHI-TANG
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Advisory Committee
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CHI-TANG HO
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chair
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DAUN
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HENRYK
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Advisory Committee
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HENRYK DAUN
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HUANG
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QINGRONG
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Advisory Committee
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QINGRONG HUANG
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internal member
Name (type = personal)
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HAO
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ZHIGANG
Affiliation
Advisory Committee
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ZHIGANG HAO
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outside member
Name (type = corporate)
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Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
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NamePart
Graduate School-New Brunswick
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school
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Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2007
DateOther (qualifier = exact); (type = degree)
2007
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
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electronic
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application/pdf
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text/xml
Extent
x, 91 pages
Abstract (type = abstract)
The importance of reactive dicarbonyl speices has been raising because of its link to many health complications. Diabetes, with the high prevalence and continued investigation on its link to methylglyoxal interested us to initiate this study. We believe that MG is involved in a vicious circle in which the elevated methylglyoxal is caused by the hyperglycemic condition and also by the consequent oxdative stress. On the other hand, the increase of methylglyoxal and oxidative stress deplete antioxidative system including glutathione and its related enzymes. This will then not only worsen the oxidative stress, but also change the route of glycolysis and other metabolisms, ketone body, fructose, etc. The vicious circle is thus turned on. We, therefore, state here that controlling the intra and extra sources and causes of methylglyoxal is of significance.
Our study first established the reliable and sensitive analytical methods for methylglyoxal determination. The combinations of proper derivatization reagents for methylglyoxal and analytical methods, GC or HPLC have been examined. Secondly, we have investigated the methylglyoxal trapping efficiency and mechanisms of dietary compounds. The kinetic studies were carried out and reaction products were characterized by LC/MS.
Tea polyphenol compounds, firstly, have shown the potential health benefits in many aspects including prevention diabetes which has the impact with methylglyoxal and methylglyoxal related AGEs. They did show the excellent trapping activity of methylglyoxal. The kinetic study and identification of EGCG-methylglyoxal products provides the preliminary understanding of the trapping mechanism by tea.
The second group, dipeptides and tripeptides, are having higher bioavailability compared to tea polyphenol compounds. The chosen dipeptides may trap methylglyoxal via formation of pyrazinone or S-(carboxyethyl)cysteine derivatives. With different side chain, most dipeptides represented different reactivity to methylglyoxal and kinetic trends. Moreover, the difference observed between triglycine and diglycine, and the one between Gly-Cys and Cys-Gly make the studying of mechanisms more essential. This varied reactivity combined with the high bioavailability, peptides may be potent to target the methylglyoxal generated at different conditions. Further consideration of their bioavailability and kinetic trends may provide the diverged and useful ways to trap methylglyoxal in vitro or in vivo.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 84-90).
Subject (authority = RUETD)
Topic
Food Science
Subject (authority = ETD-LCSH)
Topic
Plant polyphenols
Subject (authority = ETD-LCSH)
Topic
Tea
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.13730
Identifier
ETD_187
Identifier (type = doi)
doi:10.7282/T31C1XB7
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
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Copyright protected
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Open
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Name
DI TAN
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Copyright holder
Affiliation
Rutgers University. Graduate School-New Brunswick
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Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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