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Mechanical properties of the chick embryo spinal cord

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Mechanical properties of the chick embryo spinal cord
Name (ID = NAME001); (type = personal)
NamePart (type = family)
Elias
NamePart (type = given)
Ragi
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Ragi Elias
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author
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Shreiber
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David
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Advisory Committee
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David I Shreiber
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chair
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Langrana
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Noshir
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Advisory Committee
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Noshir Langrana
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internal member
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Cai
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Li
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Advisory Committee
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Li Cai
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internal member
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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school
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Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2007
DateOther (qualifier = exact); (type = degree)
2007
Language
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English
PhysicalDescription
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electronic
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application/pdf
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text/xml
Extent
ix, 38 pages
Abstract
The mechanical properties of the spinal cord dictate its response to traumatic loading conditions, and also provide important cues to cellular constituents that regulate behavior such as growth and differentiation. After initial connections are established, the structure and composition of the human spinal cord continues to significantly change during development, both pre-natally and during the early years of life. As such, the mechanical properties of the spinal cord are likely to also change, which would potentially alter both the physical tolerance of the spinal cord to injury as well as the regulatory mechanostructural cues that encourage or inhibit neural differentiation and axon growth.
Previous studies have quantified the properties of fully developed adult spinal cords from the rat, cat and human. This study quantifies the mechanical properties of the chick embryo spinal cord during a period of rapid growth and development which partially parallels the development of the post-natal human infant.
Quasistatic uniaxial tensile testing to failure was performed on chick embryo spinal cords at 0.001s-1. Samples were tested at embryological days (E) 14, 15, 16 and 18. Spinal cords demonstrated non-linear stress-strain behavior that was modeled with a 1-term Ogden hyperelastic strain energy density function. Stiffness and ultimate tensile stress (UTS) were observed with increasing development.
Stress-relaxation viscoelastic testing was also performed on spinal cords from the same development days at a loading rate consistent with those experienced during trauma (ramp to 7.5% stretch at ~19.5s-1 and hold for 10 seconds). All spinal cords demonstrated significant relaxation, and the behavior was modeled with a linear series of 4 exponential decay time constants. Statistical analysis indicated that the viscoelastic properties did not change between the days tested. Regardless of the maximum stress reached from the ramp phase, all cords tested relaxed ~72.5% with ~68% of this relaxation occurring within the first 30ms. The changes in the stiffness and UTS in the developing chick embryo spinal cord suggest similar changes in the developing human spinal cord, which points to the need for age-specific injury tolerance criteria.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references (p. 36-38).
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Biomedical Engineering
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Biomechanics
Subject (ID = SUBJ3); (authority = ETD-LCSH)
Topic
Spinal cord--Mechanical properties
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.15843
Identifier
ETD_296
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3NK3FGN
Genre (authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
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Availability
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Open
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Name
Ragi Elias
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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