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Acquired selective IgA deficiency induced by dietary bovine IgA

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Acquired selective IgA deficiency induced by dietary bovine IgA
Name (ID = NAME001); (type = personal)
NamePart (type = family)
Klartag
NamePart (type = given)
Ayelet
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Ayelet Klartag
Role
RoleTerm (authority = RULIB)
author
Name (ID = NAME002); (type = personal)
NamePart (type = family)
Ron
NamePart (type = given)
Yacov
Affiliation
Advisory Committee
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Yacov Ron
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chair
Name (ID = NAME003); (type = personal)
NamePart (type = family)
Denhardt
NamePart (type = given)
David
Affiliation
Advisory Committee
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David T Denhardt
Role
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internal member
Name (ID = NAME004); (type = personal)
NamePart (type = family)
Chen
NamePart (type = given)
Chiann-Chyi
Affiliation
Advisory Committee
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Chiann-Chyi Chen
Role
RoleTerm (authority = RULIB)
outside member
Name (ID = NAME005); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME006); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2007
DateOther (qualifier = exact); (type = degree)
2007
Language
LanguageTerm
English
PhysicalDescription
Form (authority = marcform)
electronic
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application/pdf
InternetMediaType
text/xml
Extent
ix, 32 pages
Abstract
Selective IgA deficiency (sIgAD) is the most common immunodeficiency in humans. Auto-reactive antibodies to human IgA are found in the serum of 20-40% of individuals with sIgAD. It is unknown whether these antibodies play a role in the pathogenesis of this immunodeficiency, and most researchers believe that they are secondary to the onset of sIgAD. However, it is possible that in these individuals, the anti-IgA antibodies are in fact responsible for the removal of IgA from serum, and are originally generated against xenogeneic IgA. To examine this hypothesis, the presence of anti-bovine and anti-human IgA antibodies was tested by ELISA in serum samples from IgA-deficient and control individuals. All 14 of the IgA-deficient individuals that were tested had IgG anti-bovine IgA antibodies (100%), whereas only 8 had IgG anti-human IgA antibodies (57%). Individuals with both anti-bovine and anti-human IgA antibodies always had a higher titre against bovine IgA than against human IgA. Of 18 control individuals who have normal serum levels of IgA and no anti-human IgA antibodies, a surprisingly high proportion (61%) had IgG anti-bovine IgA antibodies in their serum. These results strongly support the hypothesis that the anti-human IgA antibodies found in IgA-deficient individuals are originally produced against xenogeneic IgA, specifically bovine IgA found in dietary beef products. These antibodies can be found in many normal individuals, but only those that cross-react with endogenous human IgA will lead to the removal of IgA from circulation, and to sIgAD. Thus, sIgAD with anti-IgA antibodies is an acquired immunodeficiency, initiated by cross-reactive antibodies consumed in the diet.
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references (p. 28-32).
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Cell and Developmental Biology
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Immunoglobulin A
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16612
Identifier
ETD_422
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T37W6CKP
Genre (authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Ayelet Klartag
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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application/x-tar
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346112
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application/x-tar
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