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Evolution of cooperation among tumor cells

Descriptive

TitleInfo
Title
Evolution of cooperation among tumor cells
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
Robert
Affiliation
University of Michigan
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
David E.
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Pienta
NamePart (type = given)
Kenneth J.
Affiliation
University of Michigan Medical School
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Genetics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
Name (type = corporate)
NamePart
National Institutes of Health (U.S.)
Role
RoleTerm (authority = marcRelator)
Funder
Name (type = corporate)
NamePart
National Science Foundation (U.S.)
Role
RoleTerm (authority = marcRelator)
Funder
Name (type = corporate)
NamePart
New Jersey Commission on Cancer Research
Role
RoleTerm (authority = marcRelator)
Funder
TypeOfResource
Text
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Genre (authority = ExL-Esploro)
Accepted Manuscript
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2006
Publisher
National Academy of Sciences
Language
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English
PhysicalDescription
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manuscript
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application/pdf
Extent
6 pages
Abstract
The evolution of cooperation has a well established theoretical framework based on game theory. This approach has made valuable contributions to a wide variety of disciplines, including political science, economics, and evolutionary biology. Existing cancer theory suggests that individual clones of cancer cells evolve independently from one another, acquiring all of the genetic traits or hallmarks necessary to form a malignant tumor. It is also now recognized that tumors are heterotypic, with cancer cells interacting with normal stromal cells within the issue microenvironment, including endothelial, stromal, and nerve cells. This tumor cell???stromal cell interaction in itself is a form of commensalism, because it has been demonstrated that these nonmalignant cells support and even enable tumor growth. Here, we add to this theory by regarding tumor cells as game players whose interactions help to determine their Darwinian fitness. We marshal evidence that tumor cells overcome certain host defenses by means of diffusible products. Our original contribution is to raise the possibility that two nearby cells can protect each other from a set of host defenses that neither could survive alone. Cooperation can evolve as byproduct mutualism among genetically diverse tumor cells. Our hypothesis supplements, but does not supplant, the traditional view of carcinogenesis in which one clonal population of cells develops all of the necessary genetic traits independently to form a tumor. Cooperation through the sharing of diffusible products raises new questions about tumorigenesis and has implications for understanding observed phenomena, designing new experiments, and developing new therapeutic approaches.
Note (type = citation)
Author manuscript. Published in final edited form as: Proc Natl Acad Sci U S A. 2006 September 5; 103(36): 13474-13479.
Note (type = publisherStatement)
The final published version of this article is located at: www.pnas.org/cgi/doi/10.1073/pnas.0606053103
Note (type = grantNumber)
NIH U56 CA113004; to David E. Axelrod
Note (type = grantNumber)
R.A. was supported by National Science Foundation (NSF) Grant SES-0240852. D.E.A. was supported by NSF Grant IIS-0312953, National Institutes of Health (NIH) Grant U56 CA113004, and New Jersey Commission on Cancer Research Grant 1076-CCR-SO. K.J.P. is an American Cancer Society Clinical Research Professor and is supported by NIH Grants CA69568, CA102872, and CA093900.
Note (type = grantNumber)
NIH CA69568; to Kenneth J. Pienta
Note (type = grantNumber)
NIH CA102872; to Kenneth J. Pienta
Note (type = grantNumber)
NIH CA093900; to Kenneth J. Pienta
Note (type = grantNumber)
NSF SES-0240852; to Robert Axelrod
Note (type = grantNumber)
NJ Commission on Cancer Research 1076-CCR-SO; to David E. Axelrod
Note
Also available in PubMed Central. PMCID: PMC1557388
Subject (authority = Other)
Topic
Carcinogenesis
Subject (authority = Other)
Topic
Cancer
Subject (authority = Other)
Topic
Hallmarks
RelatedItem (type = host)
TitleInfo
Title
Axelrod, David
Identifier (type = local)
rucore30017800001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore00000001068.Article.16742
Identifier (type = FEDORA_PID)
rutgers-lib:23812
Identifier (type = doi)
doi:10.7282/T3M61HMD
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2006
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Proceedings of the National Academy of Sciences of the United States of America
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http://dx.doi.org/10.1073/pnas.0606053103
Detail
13474-13479
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National Institutes of Health
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David E. Axelrod
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NIH U56 CA113004
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National Institutes of Health
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Kenneth J. Pienta
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NIH CA69568
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National Institutes of Health
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Kenneth J. Pienta
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NIH CA102872
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National Institutes of Health
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Kenneth J. Pienta
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NIH CA093900
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National Science Foundation
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Originator
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Robert Axelrod
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Name
NSF SES-0240852
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = 1)
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National Academy of Sciences (U.S.)
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Permission or license
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David E. Axelrod
Role
Depositor
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

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application/x-tar
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