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Blood lead levels increase, but remain in normal range with severe weight reduction.

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TitleInfo
Title
Blood lead levels increase, but remain in normal range with severe weight reduction.
Name (type = personal)
NamePart (type = family)
Shapses
NamePart (type = given)
Sue
Affiliation
Nutritional Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Riedt
NamePart (type = given)
Claudia
Affiliation
4-H Youth Development, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Buckley
NamePart (type = given)
Brian
Affiliation
EOHSI, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Ambia-Sobhan
NamePart (type = given)
Hasina
Affiliation
Nutritional Sciences, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Rhoads
NamePart (type = given)
George
Affiliation
EOHSI, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Brolin
NamePart (type = given)
Robert E.
Affiliation
NJ Bariatrics and Princeton Medical Center
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Nutritional Sciences
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Environmental and Biological Sciences (SEBS)
Name (type = corporate)
NamePart
National Institutes of Health (U.S.)
Role
RoleTerm (authority = marcRelator)
sponsor
Name (type = corporate)
NamePart
National Institute of Environmental Health Sciences
Role
RoleTerm (authority = marcRelator)
sponsor
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Text
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articles
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Accepted Manuscript (AM)
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DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = inferred)
2008
Language
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English
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manuscript
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application/pdf
Extent
7 pages
Abstract
High bone turnover states are known to raise blood lead levels (BPb). Caloric restriction will increase bone turnover, yet it remains unknown if weight reduction increases BPb due to mobilization of skeletal stores. We measured whole blood Pb levels (²⁰⁶Pb) by inductively coupled plasma mass spectrometry in 73 women (age 24–75 years; BMI 23– 61 kg/m²) before and after 6 months of severe weight loss (S-WL), moderate weight loss (M-WL), or weight maintenance (WM). Baseline BPb levels were relatively low at 0.2–6.0 μg/dl, and directly associated with age (r=0.49, P<0.0001). After severe WL (-37.4±9.3 kg, n=17), BPb increased by 2.1±3.9 μg/dl (P<0.05), resulting in BPb levels of 1.3–12.5 μg/dl. M-WL (-5.6±2.7 kg, n=39) and WM (0.3±1.3 kg, n=17) did not result in an increase in BPb levels (0.5±3.2 and 0.0±0.7 μg/dl, M-WL and WM, respectively). BPb levels increased more with greater WL (r=0.24, P<0.05). Bone turnover markers increased only with severe WL and were directly correlated with WL. At baseline, higher calcium intake was associated with lower BPb (r=-0.273, P<0.02), however, this association was no longer present after 6 months. Severe weight reduction in obese women increases skeletal bone mobilization and BPb, but values remain well below levels defined as Pb overexposure.
Note
This research was supported by the NIEHS sponsored UMDNJ Center for Environmental Exposures and Disease, Grant number: NIEHS P30ES005022, in part by NIH-AG12161, and a Busch Biomedical Award to SA Shapses.
Note (type = grantNumber)
National Institutes of Health: AG12161, to S.A. Shapses
Note (type = grantNumber)
Charles & Johanna Busch Biomedical Grant, to S.A. Shapses
Note
The published version of this paper is available at: http://www.nature.com/jes
Subject (authority = Other)
Topic
Blood lead
Subject (authority = Other)
Topic
Bone turnover
Subject (authority = LCSH)
Topic
Bone remodeling
Subject (authority = LCSH)
Topic
Calcium
Subject (authority = LCSH)
Topic
Lead poisoning
Subject (authority = LCSH)
Topic
Morbid obesity
Subject (authority = LCSH)
Topic
Weight loss
RelatedItem (type = host)
TitleInfo
Title
Shapses, Sue
Identifier (type = local)
rucore30018100001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore30018100001.Article.17079
Identifier (type = doi)
doi:10.7282/T3X34VSP
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2009
AssociatedObject
Type
Journal
Relationship
Has part
Name
Journal of Exposure Science and Environmental Epidemiology
Identifier (type = volume and issue)
19
Reference (type = digital)
http://dx.doi.org/10.1038/jes.2008.5
Detail
90-96
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = 1)
Name (TYPE = corporate)
CorporateName
Nature Publishing Group
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Multiple author license v. 1
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I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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