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Spirodiepoxides: mechanism studies and applications in synthesis
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Lotesta, Stephen Dominic. Spirodiepoxides: mechanism studies and applications in synthesis. Retrieved from https://doi.org/doi:10.7282/T3PR7WBS

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Uniform TitleSpirodiepoxides: mechanism studies and applications in synthesis
NameLotesta, Stephen Dominic (author); Williams, Lawrence (chair); Knapp, Spencer (internal member); Seidel, Daniel (internal member); Ewing, William (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2008
Other Date2008-01 (degree)
SubjectChemistry and Chemical Biology, Epoxide compounds
Extentxi,353 pages
DescriptionDisclosed are studies on the mechanism and reactivity of spirodiepoxides (SDE) and their applications in synthesis. Experimental and computational data led to the establishment of three discernable mechanisms for nucleophilic opening of SDEs. New SDE-based methodologies have also been developed including the formation of functionalized azoles in a single flask from allenes and the addition of carbon nucleophiles to generate useful precursors to complex polyketides (i.e. erythromycin). Heteroatom additions to SDEs have been identified in the studies towards the potent proteasome inhibitor, epoxomicin. Syntheses of the AB spiroketal and C ring systems of the anticancer natural product, pectenotoxin 4, have also been achieved using SDE-based methods.
NotePh.D.
NoteIncludes bibliographical references.
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3PR7WBS
LanguageEnglish
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameNjNbRU
RightsThe author owns the copyright to this work.
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