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Spirodiepoxides: mechanism studies and applications in synthesis

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TypeOfResource
Text
TitleInfo (ID = T-1); (type = uniform)
Title
Spirodiepoxides: mechanism studies and applications in synthesis
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17154
Identifier
ETD_742
Language
LanguageTerm
English
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Epoxide compounds
Abstract
Disclosed are studies on the mechanism and reactivity of spirodiepoxides (SDE) and their applications in synthesis. Experimental and computational data led to the establishment of three discernable mechanisms for nucleophilic opening of SDEs. New SDE-based methodologies have also been developed including the formation of functionalized azoles in a single flask from allenes and the addition of carbon nucleophiles to generate useful precursors to complex polyketides (i.e. erythromycin). Heteroatom additions to SDEs have been identified in the studies towards the potent proteasome inhibitor, epoxomicin. Syntheses of the AB spiroketal and C ring systems of the anticancer natural product, pectenotoxin 4, have also been achieved using SDE-based methods.
PhysicalDescription
Extent
xi,353 pages
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application/pdf
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Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references.
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Lotesta
NamePart (type = given)
Stephen Dominic
Role
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author
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Stephen Dominic Lotesta
Name (ID = NAME-2); (type = personal)
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Williams
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Lawrence
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chair
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Advisory Committee
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Lawrence J Williams
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Knapp
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Spencer
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internal member
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Advisory Committee
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Spencer Knapp
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Seidel
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Daniel
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internal member
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Advisory Committee
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Daniel Seidel
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Ewing
NamePart (type = given)
William
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
William Richard Ewing
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2008
DateOther (qualifier = exact); (type = degree)
2008-01
Location
PhysicalLocation (authority = marcorg)
NjNbRU
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = doi)
doi:10.7282/T3PR7WBS
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Stephen Lotesta
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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