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Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet

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TitleInfo
Title
Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
Name (type = personal)
NamePart (type = family)
Ribnicky
NamePart (type = given)
David M.
Affiliation
Biotechnology Center for Agriculture & the Environment, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Poulev
NamePart (type = given)
Alexander
Affiliation
Biotechnology Center for Agriculture & the Environment, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Cefalu
NamePart (type = given)
William T.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Raskin
NamePart (type = given)
Ilya
Affiliation
Biotechnology Center for Agriculture & the Environment, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Stewart
NamePart (type = given)
Laura K.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Soileau
NamePart (type = given)
Jeff L.
Affiliation
Department of Kinesiology, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Wang
NamePart (type = given)
Zhong Q.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Majewski
NamePart (type = given)
Martin
Affiliation
Biotechnology Center for Agriculture & the Environment, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Gettys
NamePart (type = given)
Thomas W.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
TypeOfResource
Text
Genre (authority = RULIB-FS)
articles
Genre (authority = NISO JAV)
Version of Record (VoR)
OriginInfo
Publisher
Elsevier
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2008
Language
LanguageTerm
English
PhysicalDescription
Form (authority = RULIB)
manuscript
InternetMediaType
application/pdf
Extent
8 pages
Abstract (type = abstract)
Quercetin, a polyphenolic compound and a major bioflavonoid in the human diet, has anti-inflammatory properties and has been postulated to enhance energy expenditure (EE). We sought to determine whether quercetin alters body weight, body composition, EE, and circulating markers of inflammation. At 6 weeks (W) of age, 2 cohorts of C57BL/6J mice (N = 80) were placed on one of 2 diets for 3W or 8W: (1) high fat (HF) (45% kcal fat) or (2) high fat + quercetin (HF + Q) (45% kcal fat + 0.8% quercetin). Quercetin concentrations in the diet and plasma were evaluated using mass spectrometry. Body weight, composition (nuclear magnetic resonance), and food consumption were measured weekly. Energy expenditure was measured by indirect calorimetry at 3 and 8W, and inflammatory markers were measured in plasma obtained at 8W. The presence of quercetin in the HF diet did not alter food consumption over time in the HF + Q group and did not differ from the HF group at any time point. However, circulating plasma quercetin concentrations declined between 3 and 8W. At 3W, EE was higher during both day and night phases (P <.0001) in the HF + Q group compared with the HF group; but this difference was not detected at 8W and did not translate into significant differences between the HF + Q and HF groups with respect to body weight or body composition. During the night phase, concentrations of the inflammatory markers (interferon-γ, interleukin-1α, and interleukin-4) were significantly lower when compared with HF treatment group (P <.05). Dietary supplementation with quercetin produces transient (3W) increases in EE that are not detected after 8W on the diet. A corresponding decrease in circulating quercetin between 3 and 8W suggests that metabolic adaptation may have diminished the impact of quercetin's early effect on EE and diminished its overall effect on nutrient partitioning and adiposity. However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W.
Note
This work was supported by the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS) (NIH Grant P50AT002776-01), and by support from NIH CNRU P30 DK072476 and P20 RR021945 (TWG).
Note (type = grantNumber)
NIH P50 AT002776-01; by William Cefalu
Note (type = grantNumber)
NIH CNRU P30 DK072476
Note
The published version of this article is available at: http://www.metabolismjournal.com/
Note (type = grantNumber)
NIH P20 RR021945; by Thomas W. Gettys
Subject (authority = LCSH)
Topic
Body composition
Subject (authority = LCSH)
Topic
Body weight
Subject (authority = LCSH)
Topic
Energy metabolism
Subject (authority = LCSH)
Topic
Inflammation
Subject (authority = LCSH)
Topic
Quercetin
Subject (authority = Other)
Topic
Energy expenditure
RelatedItem (type = host)
TitleInfo
Title
Ribnicky, David
Identifier (type = local)
rucore00000001163
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore00000001163.Article.17199
Identifier (type = doi)
doi:10.7282/T3FJ2F6G
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2008
AssociatedObject
Type
Journal
Relationship
Has part
Name
Metabolism Clinical and Experimental
Identifier (type = volume and issue)
57(Supp 1)
Reference (type = digital)
http://dx.doi.org/10.1016/j.metabol.2008.03.003
Detail
S39-S46
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Biotechnology Center for Agriculture & the Environment
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Copyright protected
Availability
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Open
Reason
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RightsHolder (ID = 1)
Name (TYPE = corporate)
CorporateName
Elsevier Ltd.
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Type
Permission or license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
David Ribnicky
Detail
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