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Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome

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TitleInfo
Title
Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome
Name (type = personal)
NamePart (type = family)
Ribnicky
NamePart (type = given)
David M.
Affiliation
Biotechnology Center for Agriculture & the Environment, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Cefalu
NamePart (type = given)
William T.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Kirk
NamePart (type = given)
Heather
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Liu
NamePart (type = given)
Zhijun
Affiliation
School of Renewable Natural Resources, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Eilertsen
NamePart (type = given)
Kenneth J.
Affiliation
Pennington Biomedical Research Center, Louisiana State University
Role
RoleTerm (authority = marcrt); (type = text)
author
TypeOfResource
Text
Genre (authority = RULIB-FS)
articles
Genre (authority = NISO JAV)
Version of Record (VoR)
Genre (authority = ExL-Esploro)
Journal Article
OriginInfo
Publisher
Elsevier
DateIssued (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2008
Language
LanguageTerm
English
PhysicalDescription
Form (authority = RULIB)
manuscript
InternetMediaType
application/pdf
Extent
8 pages
Abstract (type = abstract)
Epigenetics refers to heritable changes in gene expression that are not attributable to changes in DNA sequence and impacts many areas of applied and basic biology including developmental biology, gene therapy, somatic cell nuclear transfer, somatic cell reprogramming, and stem cell biology. Epigenetic changes are known to contribute to aging in addition to multiple disease states. Epigenetic changes can be influenced by environmental factors that in turn can be inherited by daughter cells during cell division and can also be inherited through the germ line. Thus, it is intriguing to consider that epigenetics, in general, may play a role in human conditions that are strongly influenced by changes in the environment and lifestyle. In particular, metabolic syndrome, a condition increasing in prevalence around the world, is one such condition for which epigenetics is postulated to contribute. Epigenetic defects (epimutations) are thought to be more easily reversible (when compared with genetic defects) and, as such, have inspired efforts to identify novel compounds that correct epimutations or preventprogression to the disease state. These efforts have resulted in the development of a rapidly growing new field being referred to as epigenetic therapy. To date, 2 classes of drugs have received the most attention, that is, DNA methyltransferase inhibitors and histone deacetylase inhibitors; but recent data suggest that botanical sources may be a rich source of agents that can potentially modulate the epigenome and related pathways and potentially be useful in attenuating the progression of many factors related to development of metabolic syndrome. This review will provide an overview of the field of epigenetics, epigenetic therapy, and the molecules currently receiving the most interest with respect to treatment, and review data on botanical compounds that show promise in this regard.
Note
This work was supported in part by NIH Grant P50AT002776-01 from the National Center for Complementary and Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS).
Note (type = grantNumber)
NIH P50 AT002776-01; by William Cefalu
Note
The published version of this article is available at: http://www.metabolismjournal.com/
Subject (authority = Other)
Topic
Botanical therapeutics
Subject (authority = LCSH)
Topic
Medicinal plants
Subject (authority = Other)
Topic
Epigenetics
Subject (authority = LCSH)
Topic
Epigenesis
Subject (authority = LCSH)
Topic
Genetic regulation
Subject (authority = LCSH)
Topic
Metabolic syndrome
RelatedItem (type = host)
TitleInfo
Title
Ribnicky, David
Identifier (type = local)
rucore00000001163
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore00000001163.Article.17200
Identifier (type = doi)
doi:10.7282/T39W0CVM
Location
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NjNbRU
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf); (qualifier = approximate)
2008
AssociatedObject
Type
Journal
Relationship
Has part
Name
Metabolism Clinical and Experiment
Identifier (type = volume and issue)
57(suppl 1)
Reference (type = digital)
http://dx.doi.org/10.1016/j.metabol.2008.03.006
Detail
S16-S23
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
William Cefalu
AssociatedObject
Type
Grant number
Name
NIH P50 AT002776-01
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Biotechnology Center for Agriculture & the Environment
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = 1)
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CorporateName
Elsevier Ltd.
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
David Ribnicky
Detail
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