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Design of polymeric delivery system with targeted drug release profiles for hydrophilic and lipophilic compounds
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Title
Design of polymeric delivery system with targeted drug release profiles for hydrophilic and lipophilic compounds
Name
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Thakur
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Rashmi A.
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Rashmi A. Thakur
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author
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Michniak
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Bozena
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Advisory Committee
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Bozena B Michniak
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chair
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You
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Goufeng
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Advisory Committee
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Goufeng You
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internal member
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Minko
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Tamara
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Advisory Committee
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Tamara Minko
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internal member
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Wei
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William
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Advisory Committee
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William Wei
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outside member
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated
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2008
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2008-01
Language
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English
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electronic
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application/pdf
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text/xml
Extent
xvii, 219 pages
Abstract
The delivery of hydrophilic drugs and macromolecules through the uppermost layer of the skin, the stratum corneum, is particularly challenging. The use of chemical enhancers, iontophoresis, sonophoresis and microneedles are some methods of overcoming the barrier properties of the skin and achieving transdermal drug delivery. One of the versatile approaches is the use of microneedles for delivery of therapeutic agents to various depths in the skin and in addition for controlled releasing drug polymer coatings. In our study silicon microneedles were coated with a polymer-drug combination. Dip coating and electrospinning, a technique of making polymer nanofibers, were two methods employed to achieve such coatings. Dual drug loading in a single electrospun scaffold was also be attempted by a novel dual spinneret technique established by us. This scaffold was created as a potential wound healing dressing. This method of electrospinning enabled inclusion of larger quantities of two actives into the same scaffold. Such electrospun polymer fibers were directly deposited on microneedles and evaluated for drug release characteristics. It is expected that this novel drug delivery system will eventually allow immediate as well as sustained release of not only hydrophilic and lipophilic compounds but also high molecular weight compounds.
Note
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Ph.D.
Note
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Includes bibliographical references (p. 191-199).
Subject
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Topic
Pharmaceutical Science
Subject
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Topic
Drug delivery systems
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Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17228
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ETD_610
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NjNbRU
Identifier
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doi:10.7282/T3M61KM7
Genre
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ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Name
Rashmi Thakur
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Permission or license
Detail
Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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