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ZnO nanotip-based acoustic wave sensors
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Title
ZnO nanotip-based acoustic wave sensors
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Zhang
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Zheng
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Zheng Zhang
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author
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Lu
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Yicheng
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Advisory Committee
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Yicheng Lu
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Sheng
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Kuang
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Advisory Committee
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Kuang Sheng
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Jiang
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Wei
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Advisory Committee
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Wei Jiang
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Galoppini
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Elena
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Advisory Committee
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Elena Galoppini
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Rutgers University
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Graduate School - New Brunswick
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theses
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2008
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2008-01
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English
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electronic
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xvi, 158 pages
Abstract
ZnO nanostructures possess unique advantages for the biosensor applications, such as giant surface areas, high sensitivity, biological compatibility, and integratability with Si-based electronics.
This dissertation addresses the development of ZnO nanotip-based acoustic wave sensors, and their biological applications. ZnO nanostructures are grown on the surfaces of various sensors, including surface acoustic wave (SAW) sensors and quartz crystal microbalance (QCM) sensors, by metalorganic chemical vapor deposition (MOCVD). The single crystalline ZnO nanotips are well aligned along the substrate normal direction, confirmed by scanning electron microscope (SEM) and X-ray diffraction (XRD) measurements, respectively. The photoluminescence (PL) measurements show the free exciton emission at room temperature, indicating superior optical property of the ZnO nanotips.
The surface wetting properties of the ZnO nanostructured sensing surfaces are studied. It is demonstrated that the contact angles on ZnO nanotips can be changed between 0 and 130 degrees. The repeatable and reversible transitions between hydrophobic and superhydrophilic status of ZnO nanostructured surfaces have been achieved by UV illumination and low temperature oxygen annealing. The transition rate has been increased by 10-times in comparison with the published results. The immobilizations of DNA oligonucleotides to ZnO nanostructures have been conducted. DNA hybridization with complementary and non-complementary second strand DNA oligonucleotide is used to study the selectivity of the SAW sensor. The radioactive labeling tests and SAW sensor responses demonstrate that by using ZnO nanotips the DNA immobilization is enhanced by a factor of 200 in comparison with using the ZnO films. A ZnO nanotip-based QCM sensor is developed. The ZnO nanotip coated QCM sensor shows a 10-times larger frequency shift than that of regular QCM sensors, when measuring the same DNA oligonucleotide solution. In addition, the superhydrophilic behaviors of the nanotip array significantly reduce the required liquid volume for effective detection and only 3% solution is required to cover the same sensing surface compared to the traditional QCM sensor. The superhydrophilic sensing surface boosts the solution taking ability; therefore, enhances the sensitivity of the QCM sensor. The functionalization of ZnO nanotips with a series of mono- or bi-functional linkers have been achieved, which makes the selective biological sensing possible on the ZnO nanotip based QCM. ZnO nanotip-based SAW and QCM sensors possess the advantages of both traditional acoustic wave sensors and ZnO nanostructures, including high efficiency, good selectivity, low cost and broad biological applications.
This dissertation addresses the development of ZnO nanotip-based acoustic wave sensors, and their biological applications. ZnO nanostructures are grown on the surfaces of various sensors, including surface acoustic wave (SAW) sensors and quartz crystal microbalance (QCM) sensors, by metalorganic chemical vapor deposition (MOCVD). The single crystalline ZnO nanotips are well aligned along the substrate normal direction, confirmed by scanning electron microscope (SEM) and X-ray diffraction (XRD) measurements, respectively. The photoluminescence (PL) measurements show the free exciton emission at room temperature, indicating superior optical property of the ZnO nanotips.
The surface wetting properties of the ZnO nanostructured sensing surfaces are studied. It is demonstrated that the contact angles on ZnO nanotips can be changed between 0 and 130 degrees. The repeatable and reversible transitions between hydrophobic and superhydrophilic status of ZnO nanostructured surfaces have been achieved by UV illumination and low temperature oxygen annealing. The transition rate has been increased by 10-times in comparison with the published results. The immobilizations of DNA oligonucleotides to ZnO nanostructures have been conducted. DNA hybridization with complementary and non-complementary second strand DNA oligonucleotide is used to study the selectivity of the SAW sensor. The radioactive labeling tests and SAW sensor responses demonstrate that by using ZnO nanotips the DNA immobilization is enhanced by a factor of 200 in comparison with using the ZnO films. A ZnO nanotip-based QCM sensor is developed. The ZnO nanotip coated QCM sensor shows a 10-times larger frequency shift than that of regular QCM sensors, when measuring the same DNA oligonucleotide solution. In addition, the superhydrophilic behaviors of the nanotip array significantly reduce the required liquid volume for effective detection and only 3% solution is required to cover the same sensing surface compared to the traditional QCM sensor. The superhydrophilic sensing surface boosts the solution taking ability; therefore, enhances the sensitivity of the QCM sensor. The functionalization of ZnO nanotips with a series of mono- or bi-functional linkers have been achieved, which makes the selective biological sensing possible on the ZnO nanotip based QCM. ZnO nanotip-based SAW and QCM sensors possess the advantages of both traditional acoustic wave sensors and ZnO nanostructures, including high efficiency, good selectivity, low cost and broad biological applications.
Note
(type = degree)
Ph.D.
Note
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Includes bibliographical references (p. 150-157).
Subject
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Topic
Electrical and Computer Engineering
Subject
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Topic
Acoustic surface wave devices
Subject
(ID = SUBJ3);
(authority = ETD-LCSH)
Topic
Biosensors
Subject
(ID = SUBJ4);
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Topic
Zinc oxide
Subject
(ID = SUBJ5);
(authority = ETD-LCSH)
Topic
Nanostructures
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Graduate School - New Brunswick Electronic Theses and Dissertations
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doi:10.7282/T3ZK5H16
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ETD doctoral
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Open
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Zheng Zhang
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Rutgers University. Graduate School - New Brunswick
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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