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Polyanhydride blends as drug delivery matrices to control biofilms, bone and nerve regeneration

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Polyanhydride blends as drug delivery matrices to control biofilms, bone and nerve regeneration
Name (ID = NAME001); (type = personal)
NamePart (type = family)
Johnson
NamePart (type = given)
Michelle Linette
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Michelle Linette Johnson
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author
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Uhrich
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Kathryn
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Advisory Committee
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Kathryn E Uhrich
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chair
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Li
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Jing
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Advisory Committee
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Jing Li
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internal member
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Taylor
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John
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Advisory Committee
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John W Taylor
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internal member
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Patwardhan
NamePart (type = given)
Dinesh
Affiliation
Advisory Committee
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Dinesh V Patwardhan
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outside member
Name (ID = NAME006); (type = corporate)
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Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
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Graduate School - New Brunswick
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school
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Text
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theses
OriginInfo
DateCreated (qualifier = exact)
2008
DateOther (qualifier = exact); (type = degree)
2008-05
Language
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English
PhysicalDescription
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electronic
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application/pdf
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text/xml
Extent
xix, 151 pages
Abstract
Biodegradable polyanhydrides were fabricated into disks, coatings, microspheres, and tubes for controlled drug delivery as well as enhanced thermal and mechanical properties. The polymer systems were evaluated as potential treatments for periodontal disease, orthopedic injuries, nerve regeneration, and biofilm formation. The polymers contained the non-steroidal anti-inflammatory drug (NSAID), salicylic acid and the antibiotic, ampicillin, in the polymer backbone, which are subsequently released as the polymers degrade. Significantly, the polymers can be fabricated into these different geometries that would not be possible with the drug molecules alone.
This dissertation characterizes the in vitro degradation of the polyanhydrides specifically for the multiple applications. Polymer degradation was monitored by high pressure liquid chromatography (HPLC) for final degradation products. The effect of physically admixing additional drugs into the polymer matrix was studied as well, where the admixed drugs were delineated from the chemically incorporated drugs by HPLC. Accelerated in vitro degradation rates were developed using highly basic media.
Mechanical and thermal properties were examined for potential orthopedic and nerve applications. The compliance and modulus of polymer blends and composites were measured to characterize the flexibility and strength of each system. Additionally, properties, such as glass transition temperature (Tg) and decomposition temperature (Td) were measured to monitor polymer changes as a result of processing and degradation.
Overall, the fundamental chemical, thermal and mechanical properties of each polyanhydride system were monitored. This dissertation describes the optimization of controlled drug release rates for specific applications through composites and blends of ceramics (hydroxyapatite), drugs (antimicrobials and NSAIDs), and polymers (polyanhydrides).
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references.
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Drug delivery systems
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17333
Identifier
ETD_1013
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3NV9JK8
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Michelle Johnson
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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