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In vitro induction of multi-antibiotic resistant phenotypes in staphyloccocus aureus by exposure to environmental waters
Descriptive
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Title
In vitro induction of multi-antibiotic resistant phenotypes in staphyloccocus aureus by exposure to environmental waters
Name
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McChesney
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Dennis J.
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Dennis J. McChesney
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author
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Katz
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Stanley
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Advisory Committee
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Stanley E Katz
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chair
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Cooper
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Keith
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Advisory Committee
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Keith Cooper
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Strom
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Peter
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Advisory Committee
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Peter F Strom
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internal member
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Uchrin
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Chrostopher
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Advisory Committee
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Chrostopher G Uchrin
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internal member
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Vowinkel
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Eric
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Advisory Committee
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Eric Vowinkel
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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theses
OriginInfo
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2008
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2008-05
Language
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English
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electronic
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vi, 124 pages
Abstract
In vitro exposure of Staphylococcus aureus strain ATTC 9144 for 10-days to environmental water samples including ambient fresh water and wastewater treatment plant influents and effluents increased the Minimum Inhibitory Concentration (MIC) values versus the controls in 11of the 51 (22%) samples assayed. Increases in the MIC values for all of the assayed antibiotics were observed in more than one sample. Antibiotic resistance, as measured by an increase in the MIC values greater than or equal to 4 times the control sample MIC value, was observed most frequently for tetracycline (22%) and the beta lactam ampicillin, (20%), and the beta lactam methicillin (18%). The aminoglycoside, kanamycin, increased the MIC values least frequently (9%). Methicillin was co-resistant with ampicillin and tetracycline in all of the methicillin resistant samples. For other antibiotics assayed for their MIC values in Staphylococcus aureus ATCC 9144 after exposure to environmental waters, all displayed multi-antibiotic resistance with ampicillin and tetracycline resistance, suggesting a common origin or assembly of resistance traits. Vancomycin resistance was present in 10% of the 40 samples assayed for its MIC, and coexisted with methicillin resistance in 75% of the vancomycin resistant samples.
Note
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Ph.D.
Note
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Includes bibliographical references (p. 111-119).
Subject
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Topic
Environmental Sciences
Subject
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Topic
Drug resistance in microorganisms
Subject
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Topic
Staphylococcus aureus
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17353
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ETD_949
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NjNbRU
Identifier
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doi:10.7282/T31836TJ
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ETD doctoral
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Rights
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The author owns the copyright to this work.
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Copyright protected
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Open
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Name
Dennis McChesney
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Copyright holder
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Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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