Staff View
Dose- and rate-dependent effects of cocaine on striatal neurons related to licking

Descriptive

TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Dose- and rate-dependent effects of cocaine on striatal neurons related to licking
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17356
Identifier
ETD_883
Language
LanguageTerm
English
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Psychology
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Neurons--Effect of drugs on
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Cocaine--Physiological effect
Abstract
To examine the role of striatal mechanisms in cocaine-induced stereotyped licking, the activity of lick-related neurons in the ventrolateral striatum of awake, freely moving rats engaged in licking was recorded before and after cocaine administration (0, 5, 10 and 20 mg/kg). Relative to zero dose, cocaine reduced lick duration and increased interlick interval, particularly at the high dose, but did not affect licking rhythm. Stereotyped licking was induced only by the high dose, evident by an increase in the number of licks in the absence of water delivery. Firing rates (FR) of striatal neurons phasically related to licking were compared between matched licks before and after injection, minimizing any influence of sensorimotor variables on changes in firing. Both increases and decreases in average FR were observed post-drug, exhibiting a dose-dependent pattern that strongly depended on pre-drug FR. At the middle and high doses relative to the zero dose group, the average FR of slow firing neurons were increased by cocaine, resulting from a general elevation of movement-related FR. By contrast, fast firing neurons showed decreased average FR only in the high dose group, with reduced FR across the entire range for these neurons. Additionally, without any drug present (prior to drug injection) FR were positively related to the strength of the correlation of FR with lick duration. Changes in behavioral correlations were demonstrated over time with no drug present (for slow firing neurons), and following cocaine administration (for slow firing neurons at all doses, and for fast firing neurons only at the high dose). Thus, differences were observed between slow and fast firing neurons in drug effects on FR, in the strength of their behavioral correlations and with respect to changes in their behavioral correlations, suggesting that fast firing neurons may be more strongly involved in the processing of movement parameters. These findings suggest that at the high dose, increased phasic activity of slow firing striatal neurons and simultaneously reduced phasic activity of fast firing striatal neurons may contribute, respectively, to the continual initiation of stereotypic movements and the absence of longer, more global movements.
PhysicalDescription
Extent
xi, 107 pages
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 96-106).
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Mittler
NamePart (type = given)
Taliah
Role
RoleTerm (authority = RULIB)
author
DisplayForm
Taliah Mittler
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
West
NamePart (type = given)
Mark
Role
RoleTerm (authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Mark O West
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Matzel
NamePart (type = given)
Louis
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Louis Matzel
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Auerbach
NamePart (type = given)
Sidney
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Sidney Auerbach
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Plummer
NamePart (type = given)
Mark
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Mark R Plummer
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2008
DateOther (qualifier = exact); (type = degree)
2008-05
Location
PhysicalLocation (authority = marcorg)
NjNbRU
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = doi)
doi:10.7282/T3DJ5FZ5
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Taliah Mittler
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Back to the top

Technical

Format (TYPE = mime); (VERSION = )
application/x-tar
FileSize (UNIT = bytes)
1558528
Checksum (METHOD = SHA1)
6e2abed1cede7b9df536431bda1e845c62a512a3
ContentModel
ETD
CompressionScheme
other
OperatingSystem (VERSION = 5.1)
windows xp
Format (TYPE = mime); (VERSION = NULL)
application/x-tar
Back to the top
Version 8.5.5
Rutgers University Libraries - Copyright ©2024