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Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Fluorescence probing of complex solvent environments: polymeric nanocarrier aggregates and rilpivirine
Name (ID = NAME001); (type = personal)
NamePart (type = family)
Steege
NamePart (type = given)
Karen Elizabeth
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Karen Elizabeth Steege
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author
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Castner
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Edward
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Advisory Committee
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Edward W Castner
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chair
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Uhrich
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Kathryn
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Advisory Committee
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Kathryn E Uhrich
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internal member
Name (ID = NAME004); (type = personal)
NamePart (type = family)
Arnold
NamePart (type = given)
Edward
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Advisory Committee
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Edward Arnold
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internal member
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NamePart (type = family)
Piotrowiak
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Piotr
Affiliation
Advisory Committee
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Piotr Piotrowiak
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outside member
Name (ID = NAME006); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME007); (type = corporate)
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Graduate School - New Brunswick
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school
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Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (qualifier = exact)
2008
DateOther (qualifier = exact); (type = degree)
2008-05
Language
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English
PhysicalDescription
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electronic
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application/pdf
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text/xml
Extent
xviii, 215 pages
Abstract
The local environment of a drug molecule in polymeric drug nanocarrier solutions impacts the bioavailability of the drug and its ability to reach its target in the biological system. The local environment and aggregation properties of small, hydrophobic molecules in aqueous polymeric micelles and nanocarrier aggregates are explored using fluorescence spectroscopy for the purpose of characterizing drug delivery formulations on molecular length scales. The
fluorescence properties of seven coumarin dyes in A-B-A triblock copolymer unimer, micelle, and gel solutions respond to changes in local solvent environment. The A-B-A copolymer is used as a model for the encapsulation
properties of three novel amphiphilic polymers designed for hydrophobic drug delivery. Rilpivirine, a novel HIV inhibitor shows solvatochromic fluorescence spectral response due to a large charge transfer between the ground and electronic excited states. The fluorescence of rilpivirine in A-B-A triblock copolymer is investigated as a method to differentiate between the aggregated and unimer forms of the solubilized drug.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references.
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Drug delivery systems
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17396
Identifier
ETD_861
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3P55NV0
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Karen Steege
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Type
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Detail
Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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