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Anti-obesity effects of resveratrol, black tea extract and caffeine in mice
Descriptive
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Text
TitleInfo
(ID = T-1)
Title
Anti-obesity effects of resveratrol, black tea extract and caffeine in mice
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17447
Identifier
ETD_1236
Language
LanguageTerm
English
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Food Science
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Weight loss preparations
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Obesity
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Tea
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Diet
Abstract
Obesity continues to be a major public health issue in the United States. The aims of this study were to investigate whether the dietary resveratrol, black tea extract, caffeine and their combination could show anti-obesity effects in CD-1 mice fed with a high-fat diet. Five groups of CD-1 mice, with 10 mice in each group, were fed with 0.06 % resveratrol (RTL), 0.2 % black tea extract (BTE) and 0.05 % caffeine (CF), as well as their combination containing 0.03 % RTL, 0.1 % BTE and 0.025 % CF for 16 weeks. Mice on the CF diet significantly (p[less than]0.01) reduced body weight gain by 46 %, while those on the RTL, BTE, CF and the combination diets showed reductions by 12 %, 14 % and 28 %, respectively. There were significant inhibitions in parametrial (77 %), retroperitoneal (77 %) fat pads and brown adipose tissue (57 %) for mice on CF group.
Mice on the BTE diet showed significant (p[less than]0.05) inhibition of leptin levels in plasma by 59 %, while those on the CF and combination diets demonstrated significant (p[less than]0.01) inhibition by 88 % and 79 %, respectively. These results suggest that diets with RTL, BTE, and CF reduced body weight gain, fat tissue depositions and leptin levels in female CD-mice during the 16-week animal studies.
Mice on the BTE diet showed significant (p[less than]0.05) inhibition of leptin levels in plasma by 59 %, while those on the CF and combination diets demonstrated significant (p[less than]0.01) inhibition by 88 % and 79 %, respectively. These results suggest that diets with RTL, BTE, and CF reduced body weight gain, fat tissue depositions and leptin levels in female CD-mice during the 16-week animal studies.
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x, 76 pages
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Note
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M.S.
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Includes bibliographical references (p. 72-75).
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Chen
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Tzu-Ying
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Tzu-Ying Chen
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HUANG
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QINGRONG
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QINGRONG HUANG
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HENRYK
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Advisory Committee
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HENRYK DAUN
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HUANG
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MOU-TUAN
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outside member
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Advisory Committee
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MOU-TUAN HUANG
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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OriginInfo
DateCreated
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2008
DateOther
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2008-10
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NjNbRU
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = doi)
doi:10.7282/T31J9B3T
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Tzu-Ying Chen
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Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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