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Ecological therapy for cancer: Defining tumors utilizing an ecosystem paradigm suggests new opportunities for novel cancer treatments

Descriptive

TitleInfo
Title
Ecological therapy for cancer: Defining tumors utilizing an ecosystem paradigm suggests new opportunities for novel cancer treatments
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
David E.
Affiliation
Genetics, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Pienta
NamePart (type = given)
Kenneth J.
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
McGregor
NamePart (type = given)
Natalie
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Axelrod
NamePart (type = given)
Robert
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Genetics
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
School of Arts and Sciences (SAS) (New Brunswick)
TypeOfResource
Text
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Genre (authority = ExL-Esploro)
Journal Article
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2008
Publisher
Neoplasia Press
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
Form (authority = RULIB)
InternetMediaType
application/pdf
Extent
6 pages
Abstract (type = abstract)
We propose that there is an opportunity to devise new cancer therapies based on the recognition that tumors have properties of ecological systems. Traditionally, localized treatment has targeted the cancer cells directly by removing them (surgery) or killing them (chemotherapy and radiation). These modes of therapy have not always been effective because many tumors recur after these therapies, either because not all of the cells are killed (local recurrence) or because the cancer cells had already escaped the primary tumor environment (distant recurrence). There has been an increasing recognition that the tumor microenvironment contains host noncancer cells in addition to cancer cells, interacting in a dynamic fashion over time. The cancer cells compete and/or cooperate with nontumor cells, and the cancer cells may compete and/or cooperate with each other. It has been demonstrated that these interactions can alter the genotype and phenotype of the host cells as well as the cancer cells. The interaction of these cancer and host cells to remodel the normal host organ microenvironment may best be conceptualized as an evolving ecosystem. In classic terms, an ecosystem describes the physical and biological components of an environment in relation to each other as a unit. Here, we review some properties of tumor microenvironments and ecological systems and indicate similarities between them. We propose that describing tumors as ecological systems defines new opportunities for novel cancer therapies and use the development of prostate cancer metastases as an example.We refer to this as “ecological therapy” for cancer.
Subject (authority = LCSH)
Topic
Cancer
Subject (authority = LCSH)
Topic
Tumors
Subject (authority = LOCAL)
Topic
Therapy
Subject (authority = LOCAL)
Topic
Microenvironment
Subject (authority = LCSH)
Topic
Tumor microenvironment
Subject (authority = LCSH)
Topic
Cancer--Treatment
RelatedItem (type = host)
TitleInfo
Title
Axelrod, David
Identifier (type = local)
rucore30017800001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore30017800001.Article.17658
Identifier (type = doi)
doi:10.7282/T347487Q
Location
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NjNbRU
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2008
AssociatedObject
Type
Journal
Relationship
Has part
Name
Translational Oncology
Identifier (type = volume and issue)
1(4)
Reference (type = digital)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582164/
Detail
158-164
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
David E. Axelrod
AssociatedObject
Type
Grant number
Name
CA113004
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
AssociatedObject
Type
Grant number
Name
CA093900
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of health
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
AssociatedObject
Type
Grant number
Name
P50 CA69568
Detail
Specialized Program of Research Excellence
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Cancer Center
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
AssociatedObject
Type
Grant number
Name
P30 CA 46592
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
SouthWest Oncology Group
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
AssociatedObject
Type
Grant number
Name
CA32102
Extension
DescriptiveEvent
Type
Grant award
Detail
Clinical Research Professorship
AssociatedEntity
Role
Funder
Name
American Cancer Society
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Prostate Cancer Foundation
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
Ralph Wilson Medical Research Foundation
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
Extension
DescriptiveEvent
Type
Grant award
Detail
Translational Partners
AssociatedEntity
Role
Funder
Name
Wallace H. Coulter Foundation
AssociatedEntity
Role
Originator
Name
Pienta, Kenneth J.
Extension
DescriptiveEvent
Type
Grant award
Detail
LS&A Enrichment Fund
AssociatedEntity
Role
Funder
Name
University of Michigan
AssociatedEntity
Role
Originator
Name
Axelrod, Robert M.
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RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = 1)
Name (TYPE = corporate)
CorporateName
Translational Oncology
RightsHolder (ID = 2)
Name (TYPE = corporate)
CorporateName
University of Michigan
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
University of Michigan
Role
Copyright holder
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers. Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work. I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others. I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work. By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

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application/x-tar
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661504
Checksum (METHOD = SHA1)
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PreservationLevel
High
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