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Differentiation of human and murine embryonic stem cells: studies on the combined roles of adhesion molecules and growth factors

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TitleInfo (displayLabel = Citation Title); (type = uniform)
Title
Differentiation of human and murine embryonic stem cells: studies on the combined roles of adhesion molecules and growth factors
TitleInfo (displayLabel = Other Title); (type = alternative)
Title
Studies on the combined roles of adhesion molecules and growth factors
Name (ID = NAME001); (type = personal)
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Moore
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Rebecca
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Rebecca Moore
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author
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Moghe
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Prabhas
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Advisory Committee
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Prabhas V Moghe
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chair
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Grumet
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Martin
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Advisory Committee
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Martin Grumet
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co-chair
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Ramsey
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Advisory Committee
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Ramsey Foty
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internal member
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Cohen
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Rick
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Advisory Committee
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Rick I Cohen
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outside member
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Rutgers University
Role
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degree grantor
Name (ID = NAME007); (type = corporate)
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Graduate School - New Brunswick
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school
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Text
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theses
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2008
DateOther (qualifier = exact); (type = degree)
2008-10
Language
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English
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electronic
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application/pdf
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text/xml
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x, 147 pages
Abstract
The field of stem cell bioengineering can potentially revolutionize cell-based therapies for functional replacement of complex systems like the liver and nervous system. Despite significant challenges ahead, mouse and human embryonic stem (ES) cells can serve as a potential cell source for transplantation medicine, and efforts are being actively directed to guide ES cell development and maturation [1-3]. The murine ES cell model has been demonstrated to be highly organotypic based on its successful realization of specific lineages [4], but current efforts have been focused toward human ES differentiation. Despite the many research efforts, the molecular signals that can effectively promote the integration and specific differentiation of ES cells are not well characterized.
In this dissertation, I examined the molecular and microscale parameters governing the differentiation of embryonic stem cells into hepatic and neural tissue. The goals of this study are two-fold; first, we sought to identify the nature of and presentation approaches for molecular signals that promote the liver-specific maturation of mouse and human ES cells through cell-cell adhesion molecule, E-cadherin, and growth factor stimulation. Secondly, we investigated the effects of E-cadherin on neural differentiation of human ES cells. Overall, our hypothesis is that optimal combinations of molecular growth factors and the presentation of cell adhesion molecules can provide effective tools for regenerative and reparative medicine for cell-based therapy.
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 127-146).
Subject (ID = SUBJ1); (authority = RUETD)
Topic
Biomedical Engineering
Subject (ID = SUBJ2); (authority = ETD-LCSH)
Topic
Cell differentiation
Subject (ID = SUBJ3); (authority = ETD-LCSH)
Topic
Cell adhesion molecules
Subject (ID = SUBJ4); (authority = ETD-LCSH)
Topic
Cells--Growth
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17535
Identifier
ETD_1188
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3ZC834N
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
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Copyright protected
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Open
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Name
Rebecca Moore
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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