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Three-dimensional computational modeling and simulation of cell rolling and deformation on an adhesive surface in shear flow
Descriptive
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Title
Three-dimensional computational modeling and simulation of cell rolling and deformation on an adhesive surface in shear flow
Name
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Pappu
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Vijay
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Vijay Pappu
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Bagchi
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Advisory Committee
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Prosenjit Bagchi
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Abdelfattah
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Zebib
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Advisory Committee
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Zebib M.G. Abdelfattah
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internal member
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Doyle
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Knight
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Advisory Committee
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Knight D Doyle
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Rutgers University
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Graduate School - New Brunswick
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theses
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2008
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2008-10
Language
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English
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electronic
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xxii, 131 pages
Abstract
Three-dimensional computational modeling and simulations are presented on the rolling motion of a deformable cell on an adhesive surface in shear flow. The problem is motivated primarily by the adhesive rolling motion of white blood cells or leukocytes in response to inflammation in the body. The methodology is based on an immersed boundary method to predict cell deformation, and a Monte Carlo simulation to model the random formation and breakage of the adhesion bonds formed between a ligand-bearing cell and a receptor-coated surface. The multiscale and multiphysics modeling developed in this study allows us to resolve the complex coupling between the hydrodynamics, the deformation dynamics of the cell, and the biophysics of the adhesion bonds. In the thesis, we address the sequence of events that are encountered in the multistep process of cell rolling, namely, the initial arrest of the cell, followed by its deformation and spreading on the substrate, and the subsequent quasi-steady rolling motion. We provide phase diagrams for cell adhesion/escape, and showed that the hydrodynamic lift, that exists on a deformable cell in the wall-bounded motion, plays a major role in the process. The experimentally observed 'stop-and-go' motion of the cells is predicted in our simulations. After providing results on the general adhesive rolling motion, we focus specifically on the rolling dynamics of the leukocytes, and study the effect of cell deformability, shear rate and cell concentration on the instantaneous and time-averaged rolling characteristics. We also study the biophysical characteristics of the adhesion bonds during the rolling process. Finally, we consider the effect of the adherent leukocytes on the surrounding flow in terms of the changes in tracer dispersion and the vascular flow resistance. Comparison with experimental measurements (in vitro and in vivo) is presented throughout the thesis.
Note
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M.S.
Note
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Includes bibliographical references (p. 125-131).
Subject
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Topic
Mechanical and Aerospace Engineering
Subject
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Topic
Cell adhesion--Mathematical models
Subject
(ID = SUBJ3);
(authority = ETD-LCSH)
Topic
Blood cells--Deformability
Subject
(ID = SUBJ4);
(authority = ETD-LCSH)
Topic
Fluid dynamics--Mathematical models
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17542
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ETD_1202
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doi:10.7282/T3VM4CJ9
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ETD graduate
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Open
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Vijay Pappu
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Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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