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Synthesis and evaluation of amphiphilic scorpion-like and star macromolecules for biomedical applications
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Synthesis and evaluation of amphiphilic scorpion-like and star macromolecules for biomedical applications
Identifier
ETD_1406
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000050505
Language
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eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Drug delivery systems
Abstract
Self-assembled and unimolecular amphiphilic macromolecules with pseudo-double branched and single tails were synthesized. Degradation behavior, drug loading efficiency, drug release rate and stability of macromolecules were investigated. The anti-tumor drug, Camptothecin and the anti-inflammatory drug, Indomethacin were used to evaluate drug loading and release efficiency. Unimolecular amphiphilic macromolecules were more stable in the presence of the enzyme, lipase and human serum albumin (HSA) compared to self-assembled macromolecules. Pseudo-branched macromolecules drug release rate was slower compared to linear macromolecules.
Furthermore, self-assembled single tail amphiphilic macromolecule (AScMs) were modified to achieve active tumor targeting and to achieve high concentration of drug with cyclo(RGDfk) and Doxorubicin, respectively. Cyclo(RGDfk) conjugated AScMs showed higher uptake in tumor cells compared to AScMs alone. Furthermore, AScMs and Cyclo(RGDfk)-AScMs showed similar uptake profile with healthy cells. Higher loading efficiency was determined in Doxorubicin conjugated AScMs. On the other hand, lower IC50 value (high toxicity) was determined by AScMs-Dox conjugation.
Self-assembled pseudo branched macromolecules were modified with two carboxylate acids to achieve higher Low Density Lipoprotein (LDL) uptake. LDL uptake of branched macromolecules was compared with linear self-assembled macromolecules which are modified with carboxylic acid and sulfuric acid by our group members. Two carboxylate acid conjugated-AScMs (2CM branched) achieved the highest LDL uptake compared to other macromolecules.
Furthermore, self-assembled single tail amphiphilic macromolecule (AScMs) were modified to achieve active tumor targeting and to achieve high concentration of drug with cyclo(RGDfk) and Doxorubicin, respectively. Cyclo(RGDfk) conjugated AScMs showed higher uptake in tumor cells compared to AScMs alone. Furthermore, AScMs and Cyclo(RGDfk)-AScMs showed similar uptake profile with healthy cells. Higher loading efficiency was determined in Doxorubicin conjugated AScMs. On the other hand, lower IC50 value (high toxicity) was determined by AScMs-Dox conjugation.
Self-assembled pseudo branched macromolecules were modified with two carboxylate acids to achieve higher Low Density Lipoprotein (LDL) uptake. LDL uptake of branched macromolecules was compared with linear self-assembled macromolecules which are modified with carboxylic acid and sulfuric acid by our group members. Two carboxylate acid conjugated-AScMs (2CM branched) achieved the highest LDL uptake compared to other macromolecules.
PhysicalDescription
Extent
xii, 59 p. : ill.
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Note
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M.S.
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Includes bibliographical references.
Note
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by Bahar Demirdirek
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Demirdirek
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Bahar
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bahardem@rci.rutgers.edu/bahardem@gmail.com
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Bahar Demirdirek
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Uhrich
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Kathryn
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chair
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Advisory Committee
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Kathryn Uhrich
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Uhrich
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Kathryn
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chair
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Advisory Committee
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Kathryn E. Uhrich
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Castner
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Edward
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internal member
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Advisory Committee
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Edward Castner
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Jimenez
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Leslie
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internal member
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Advisory Committee
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Leslie Jimenez
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2009
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2009-01
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xx
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T3JM29WD
Genre
(authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
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Copyright protected
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Open
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Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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491520
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