DescriptionIn this thesis surface decontamination via USP (ultra-short pulse) laser ablation is experimentally investigated. A Raydiance laser(0.9 or 1.2 ps, 1552nm, 1-5μJ, 1-500kHz) is employed. By focusing the high peak intensity, ultra-short pulse laser beam into a small spot and scanned over the contaminated area, material removal via plasma-mediated ablation is implemented with micro-joule level pulses. Laser ablation features of different materials such as glass, PDMS polymer and blood contamination are studied. By targeting a thin film or distributed surface contaminants with the USP laser decontamination results at varies laser parameters are examined. By carefully aligning the laser focus removal at cellular level is demonstrated. Utilizing the advantages of USP laser, we successfully achieved optimum surface decontamination results on soft biological phantom and skin dermis tissue. The experiment results are evaluated by a digital microscope or SEM. The Ultra-short pulse laser ablation technique offers a promising alternative to the current surface processing and decontamination method in bio-medical applications.