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Urinary 1-hydroxypyrene in nonsmokers
Descriptive
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Text
TitleInfo
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Title
Urinary 1-hydroxypyrene in nonsmokers
SubTitle
a biomarker for coke smoke exposure and general urban PAH exposure
PartName
PartNumber
NonSort
Identifier
ETD_699
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051016
Language
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eng
Genre
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theses
Subject
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(authority = RUETD)
Topic
Public Health
Subject
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(authority = ETD-LCSH)
Topic
Coke-oven gas--Toxicology
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Iron and steel workers--Health risk assessment
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Industrial hygiene
Abstract
This dissertation research examined the validity of urinary 1-OHP as a biomarker of PAH for coke production workers and non-coke oven workers in Anshan City, China. It has been examined whether a first morning urine sample can be used to reflect daily average exposure. Results show that intra-individual differences ranged from 40% to 62% between first morning voids and 24-hour urine composite urine samples. Coke workers showed larger intra-individual differences than non-coke oven workers. Creatinine adjustment of 1-OHP in urine reduced intra-individual difference by approximately 10% for both coke and non-coke oven workers. Despite significant intra-individual difference, a high overall correlation (r=0.76) was observed between first morning and 24-hour average 1-OHP concentrations. Significant effect of season on the association between first morning and 24-hour 1-OHP in urine has been observed. Creatinine adjustment did not improve overall correlation between 1-OHP concentrations in first morning voids and 24-hour composite urine samples.
An exposure-biomarker relationship between PAH exposure and urinary 1-OHP concentration has been determined with a wide range of personal inhalation exposure., suggesting a threshold value for this exposure-biomarker relationship at 49 ng/m3 for personal air pyrene and 20 ng/m3 for personal air BaP. The corresponding urinary 1-OHP concentration was 0.46 ?mol/(mol creatinine). However, no significant exposure-biomarker relationship was observed for dietary intake. With inhalation exposure, an increase of 1-OHP concentration by 1 ?mol/(mol creatinine) predicted an increase in personal air concentration of BaP by 0.12 ?g/m3 and 0.13 ?g/m3 in males and females, respectively.
In addition, reproducibility of urinary 1-OHP has been demonstrated over 6 to 9 months. Intra-class correlation coefficient for urinary 1-OHP was similar to those for personal air and dietary intakes of pyrene. Within-person variances were larger than between-person variances in all measured media. Urinary 1-OHP had the highest variance ratio (within- to between-person), suggesting that urinary 1-OHP may be less accurate to estimate PAH exposure than personal air and dietary intake. No significant effects of work type and season were found on intra-class correlation in urinary 1-OHP, personal air concentration of pyrene, and dietary pyrene intake.
An exposure-biomarker relationship between PAH exposure and urinary 1-OHP concentration has been determined with a wide range of personal inhalation exposure., suggesting a threshold value for this exposure-biomarker relationship at 49 ng/m3 for personal air pyrene and 20 ng/m3 for personal air BaP. The corresponding urinary 1-OHP concentration was 0.46 ?mol/(mol creatinine). However, no significant exposure-biomarker relationship was observed for dietary intake. With inhalation exposure, an increase of 1-OHP concentration by 1 ?mol/(mol creatinine) predicted an increase in personal air concentration of BaP by 0.12 ?g/m3 and 0.13 ?g/m3 in males and females, respectively.
In addition, reproducibility of urinary 1-OHP has been demonstrated over 6 to 9 months. Intra-class correlation coefficient for urinary 1-OHP was similar to those for personal air and dietary intakes of pyrene. Within-person variances were larger than between-person variances in all measured media. Urinary 1-OHP had the highest variance ratio (within- to between-person), suggesting that urinary 1-OHP may be less accurate to estimate PAH exposure than personal air and dietary intake. No significant effects of work type and season were found on intra-class correlation in urinary 1-OHP, personal air concentration of pyrene, and dietary pyrene intake.
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electronic resource
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xii, 146 p. : ill.
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Ph.D.
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Includes bibliographical references.
Name
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Han
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In-Kyu
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In-Kyu Han
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Zhang
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Junfeng (Jim)
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chair
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Advisory Committee
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Junfeng (Jim) Zhang
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Robson
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Mark
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Mark Robson
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Ohman-Strickland
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Pamela
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Pamela Ohman-Strickland
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Barr
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Dana
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outside member
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Advisory Committee
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Dana Barr
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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2008
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2008-01
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Rutgers University Electronic Theses and Dissertations
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ETD
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
Identifier
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doi:10.7282/T37M086G
Genre
(authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
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Copyright protected
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Open
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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