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Tissue engineered braided hybrid fiber scaffold for anterior cruciate ligament reconstruction

Descriptive

TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Tissue engineered braided hybrid fiber scaffold for anterior cruciate ligament reconstruction
Identifier
ETD_1441
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051076
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Biomedical Engineering
Subject (ID = SBJ-1); (authority = ETD-LCSH)
Topic
Anterior cruciate ligament
Subject (ID = SBJ-1); (authority = ETD-LCSH)
Topic
Joints--Regeneration
Abstract
The knee joint is the largest and most complex joint in the human body. Its stability is largely dependent on the anterior cruciate ligament (ACL), a dense fibrous connective tissue that attaches the femur to the tibia. Under high tensile and torsional forces the ACL will tear and does not heal without surgical intervention. This is due to the low blood supply and ligament retraction from the synovial tissue that envelops a tear. We explored the potential of a novel ACL reconstructive device composed of a hybrid poly(desaminotyrosyl-tyrosine dodecyl dodecanedioate)(12,10) [p(DTD DD)] and type I bovine collagen fiber scaffold as an alternative to current autograft and allografts techniques. The three phase process initially tested the fabrication and characterization of p(DTD DD) fibers and compared them to poly(L-lactic acid) (PLLA), a common biomaterial. Data suggested that p(DTD DD) fibers, with their higher strength, lower stiffness, favorable degradation products and comparable cell compatibility, may be a superior alternative to PLLA fibers for development of an ACL reconstructive device. The second phase tested electron beam (E-beam) sterilized hybrid scaffolds composed of parallel 75% p(DTD DD) and 25% collagen fibers. Hybrid scaffolds were implanted for up to 4 weeks in the ACL space of New Zealand White (NZW) rabbits. At 4 weeks there was far more cell infiltration, vascular tissue and granuloma. Inflammatory cells were concentrated on the outer part of the scaffold, which is the natural repair reaction to surgery and not the implant. The third phase used a similar scaffold in a braided configuration, a larger sheep model and a longer 12 week time point. Analysis showed an increase in the amount of cellular infiltration and vascular tissue after 12 weeks. There was a decrease in the amount of eosinophils and no change in the number of multi nucleated giant cells after 12 weeks. Cellular infiltration was apparent at the center of the scaffold, which suggests that spacing between fibers is large enough to allow cells to migrate freely throughout the scaffold. Data suggests there is a definite potential in using a braided hybrid fiber scaffold composed of p(DTD DD) and Collagen as an ACL reconstructive device.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
xii, 115 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 102-113)
Note (type = statement of responsibility)
by Nicky Tovar
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Tovar
NamePart (type = given)
Nicky
Role
RoleTerm (authority = RULIB); (type = )
author
DisplayForm
Nicky Tovar
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
Dunn
NamePart (type = given)
Michael
Role
RoleTerm (authority = RULIB); (type = )
chair
Affiliation
Advisory Committee
DisplayForm
Michael G. Dunn
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Gatt
NamePart (type = given)
Charles
Role
RoleTerm (authority = RULIB); (type = )
internal member
Affiliation
Advisory Committee
DisplayForm
Charles Gatt
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Jaffe
NamePart (type = given)
Michael
Role
RoleTerm (authority = RULIB); (type = )
internal member
Affiliation
Advisory Committee
DisplayForm
Michael Jaffe
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Bourke
NamePart (type = given)
Sharon
Role
RoleTerm (authority = RULIB); (type = )
outside member
Affiliation
Advisory Committee
DisplayForm
Sharon L. Bourke
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB); (type = )
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB); (type = )
school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2009
DateOther (qualifier = exact); (type = degree)
2009-01
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3J103CK
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

ContentModel
ETD
MimeType (TYPE = file)
application/pdf
MimeType (TYPE = container)
application/x-tar
FileSize (UNIT = bytes)
2693120
Checksum (METHOD = SHA1)
f11926097a9fbc87eddb80ab55270d3c5d5dbeaf
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