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Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion
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Baliga, Sunanda S.. Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion. Retrieved from https://doi.org/doi:10.7282/T35X295P

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TitleAcetaminophen confers neuroprotection during early cerebral ischemia-reperfusion
NameBaliga, Sunanda S. (author); Weiss, Harvey (chair); Firestein, Bonnie (internal member); Merrill, Gary (internal member); Ma, Jianjie (internal member); Denhardt, David (outside member); Rutgers University; Graduate School - New Brunswick
Date Created
Other Date2009-05 (degree)
SubjectPhysiology and Integrative Biology, Cerebral ischemia--Treatment, Cerebrovascular disease--Treatment, Acetaminophen
Extentix, 116 p. : ill.
DescriptionStroke is the leading cause of disability in the United States. It usually occurs from a clot blocking a cerebral artery, resulting in cerebral ischemia and infarction. Few stroke therapeutics are available that definitively improve patient outcome. Acetaminophen is a readily available, inexpensive drug with a good safety profile - properties desirable of a neuroprotectant. We have previously shown acetaminophen to be effective following myocardial infarction. Since similar cell-destructive events occur during cerebral ischemia as in myocardial infarction, we sought to determine whether acetaminophen would protect neuronal cells in a similar fashion. Biochemical and molecular assays were employed to assess cell death and mitochondrial function. Acetaminophen significantly reduced cerebral infarct size, mitochondrial swelling and rupture as well as apoptosis. Acetaminophen also preserved mitochondrial membrane potential. Furthermore, acetaminophen prevented cerebral edema, as seen histopathologically. Taken together, these data suggest that acetaminophen is effective in preventing neuronal stroke damage.
NotePh.D.
NoteIncludes bibliographical references (p. 95-114)
Noteby Sunanda S. Baliga
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T35X295P
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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