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Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion
Descriptive
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Text
TitleInfo
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Title
Acetaminophen confers neuroprotection during early cerebral ischemia-reperfusion
Identifier
ETD_1738
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051174
Language
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eng
Genre
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theses
Subject
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(authority = RUETD)
Topic
Physiology and Integrative Biology
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Cerebral ischemia--Treatment
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Cerebrovascular disease--Treatment
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Acetaminophen
Abstract
Stroke is the leading cause of disability in the United States. It usually occurs from a clot blocking a cerebral artery, resulting in cerebral ischemia and infarction. Few stroke therapeutics are available that definitively improve patient outcome. Acetaminophen is a readily available, inexpensive drug with a good safety profile - properties desirable of a neuroprotectant. We have previously shown acetaminophen to be effective following myocardial infarction. Since similar cell-destructive events occur during cerebral ischemia as in myocardial infarction, we sought to determine whether acetaminophen would protect neuronal cells in a similar fashion. Biochemical and molecular assays were employed to assess cell death and mitochondrial function. Acetaminophen significantly reduced cerebral infarct size, mitochondrial swelling and rupture as well as apoptosis. Acetaminophen also preserved mitochondrial membrane potential. Furthermore, acetaminophen prevented cerebral edema, as seen histopathologically. Taken together, these data suggest that acetaminophen is effective in preventing neuronal stroke damage.
PhysicalDescription
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electronic resource
Extent
ix, 116 p. : ill.
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application/pdf
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text/xml
Note
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Ph.D.
Note
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Includes bibliographical references (p. 95-114)
Note
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by Sunanda S. Baliga
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Baliga
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Sunanda S.
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1982
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author
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Sunanda S. Baliga
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Weiss
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Harvey
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chair
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Advisory Committee
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Harvey Weiss
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Firestein
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Bonnie
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internal member
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Advisory Committee
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Bonnie L. Firestein
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Merrill
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Gary
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internal member
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Advisory Committee
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Gary F. Merrill
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Ma
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Jianjie
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internal member
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Advisory Committee
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Jianjie Ma
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Denhardt
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David
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outside member
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Advisory Committee
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David T. Denhardt
Name
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2009
DateOther
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2009-05
Place
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xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T35X295P
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Detail
Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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ETD
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application/pdf
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application/x-tar
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3522560
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