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The functional anatomy of hippocampal theta and gamma oscillations
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Text
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Title
The functional anatomy of hippocampal theta and gamma oscillations
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The
Identifier
ETD_1419
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000051286
Language
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eng
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theses
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Topic
Integrative Neuroscience
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Oscillations
Abstract
This dissertation investigated how theta (4-10Hz) and gamma (40-100Hz) oscillations are coordinated across different hippocampal subnetworks during different behaviors. Using 96-site silicon probes to simultaneously record local field potentials (LFPs) and unit activity from dendritic and somatic layers of the dentate gyrus, CA3 and CA1 regions, I examined how local field potentials (LFPs) and unit activity changed the theta and gamma synchronization of hippocampal networks as a function of behavior. Specifically, I compared hippocampal activity of rats during performance of a hippocampus-dependent delayed spatial alternation task on a modified T-maze versus performance of non-mnemonic control tasks. I also compared hippocampal network activity during active waking behavior versus rapid eye movement (REM) sleep.
The first study examined how theta oscillations throughout the hippocampal subnetworks change during behavioral task performance. Although theta oscillations were generally highly coherent throughout the system, I found that the power, coherence and phase of theta oscillations fluctuated in a layer-specific manner, suggesting the presence of multiple interdependent dipoles. I also found layer-specific changes in theta power and coherence during different portions of both alternation and control tasks, as well as a decreased phase lag between CA3 and CA1 theta oscillations on the center arm of the T-maze compared to other segments of the alternation and control tasks.
The second study examined changes in hippocampal gamma oscillations during performance of the alternation and control tasks. This study found that on the center arm of the T-maze, the power and coherence of gamma oscillations at the CA3-CA1 interface increased compared to other segments in the alternation task or compared to control task segments.
The third study examined changes in theta and gamma coordination of hippocampal networks during active waking versus REM sleep. I found increased dentate/CA3 theta and gamma synchrony, but decreased CA3-CA1 gamma coordination during REM sleep. I also detected phasic bursts of LFP power in the dentate molecular layer that divided REM sleep into phasic and tonic periods. Although tonic periods characterized the majority of REM sleep epochs (~95%), phasic periods exhibited transient increases in theta and gamma coordination among all of the hippocampal subregions.
The first study examined how theta oscillations throughout the hippocampal subnetworks change during behavioral task performance. Although theta oscillations were generally highly coherent throughout the system, I found that the power, coherence and phase of theta oscillations fluctuated in a layer-specific manner, suggesting the presence of multiple interdependent dipoles. I also found layer-specific changes in theta power and coherence during different portions of both alternation and control tasks, as well as a decreased phase lag between CA3 and CA1 theta oscillations on the center arm of the T-maze compared to other segments of the alternation and control tasks.
The second study examined changes in hippocampal gamma oscillations during performance of the alternation and control tasks. This study found that on the center arm of the T-maze, the power and coherence of gamma oscillations at the CA3-CA1 interface increased compared to other segments in the alternation task or compared to control task segments.
The third study examined changes in theta and gamma coordination of hippocampal networks during active waking versus REM sleep. I found increased dentate/CA3 theta and gamma synchrony, but decreased CA3-CA1 gamma coordination during REM sleep. I also detected phasic bursts of LFP power in the dentate molecular layer that divided REM sleep into phasic and tonic periods. Although tonic periods characterized the majority of REM sleep epochs (~95%), phasic periods exhibited transient increases in theta and gamma coordination among all of the hippocampal subregions.
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electronic resource
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xii, 187 p. : ill.
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Supplementary File: Figure 1.1
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Supplementary File: Figure 2.1
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Supplementary File: Figure 2.2
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Supplementary File: Figure 2.3
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Supplementary File: Figure 2.4
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Supplementary File: Figure 2.5
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Supplementary File: Figure 2.6
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Supplementary File: Figure 2.7
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Supplementary File: Figure 2.S1
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Supplementary File: Figure 2.S2
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Supplementary File: Figure 2.S3
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Supplementary File: Figure 2.S4
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Supplementary File: Figure 2.S5
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Supplementary File: Figure 3.1
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Supplementary File: Figure 3.2
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Supplementary File: Figure 3.3
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Supplementary File: Figure 3.4
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Supplementary File: Figure 3.5
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Supplementary File: Figure 3.S1
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Supplementary File: Figure 3.S2
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Supplementary File: Figure 3.S3
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Supplementary File: Figure 3.S4
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Supplementary File: Figure 3.S5
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Supplementary File: Figure 3.S6
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Supplementary File: Figure 4.1
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Supplementary File: Figure 4.2
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Supplementary File: Figure 4.3
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Supplementary File: Figure 4.4
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Supplementary File: Figure 4.5
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Supplementary File: Figure 4.6
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Supplementary File: Figure 4.7
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Supplementary File: Figure 4.S1
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Supplementary File: Figure 4.S2
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Supplementary File: Figure 4.S3
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Supplementary File: Figure 4.S4
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Supplementary File: Figure 4.S5
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Supplementary File: Figure 4.S6
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Supplementary File: Movie 3.S1
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Supplementary File: Movie 3.S2
Note
(type = degree)
Ph.D.
Note
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Includes bibliographical references (p. 124-148)
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by Sean M. Montgomery
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Sean M.
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James
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James M Tepper
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Denis
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Denis Pare
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Harris
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Kenneth D Harris
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Buzsaki
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Gyorgy
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Gyorgy Buzsaki
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Kahana
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Michael
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Michael J Kahana
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Rutgers University
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Graduate School - Newark
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2009
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2009-01
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xx
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Rutgers University Electronic Theses and Dissertations
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Graduate School - Newark Electronic Theses and Dissertations
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doi:10.7282/T3K937RC
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ETD doctoral
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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