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The role of SEPT2 on neuronal development
Descriptive
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Text
TitleInfo
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Title
The role of SEPT2 on neuronal development
SubTitle
PartName
PartNumber
NonSort
Identifier
ETD_1646
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051363
Language
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eng
Genre
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theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Cell and Developmental Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Septins
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Developmental neurobiology
Abstract
Septins constitute a family of evolutionarily conserved proteins that were first discovered for their involvement in cell division. Recently, they are also found to be increasingly important in various neurodegenerative states, such as Parkinson's and Alzheimer's diseases. Molecular mechanisms underlying the function of septin proteins in the nervous system, however, remain largely unknown. Work from this thesis revealed that a member of the septin family, SEPT2, is important for exocytosis underlying neurite outgrowth in PC12 cells. SEPT2 has a similar tissue distribution and developmental expression profile as that of sec15, a subunit of the exocyst complex which has been found to be required for exocytosis. In undifferentiated PC12 cells, SEPT2 exhibited perinuclear enrichment, as observed for exocyst subunits. Upon neuronal differentiation, SEPT2, like exocyst subunits, redistributes from its perinuclear enrichment to the neurites and the growth cones. Knockdown of SEPT2 disrupted the perinuclear enrichment of exocyst subunits, decreased the protein levels of exocyst subunits. Under this condition, neurite outgrowth and the insertion of protein into the plasma membrane of PC12 cells were inhibited. These results suggest a novel mechanism by which SEPT2 can mediate and/or regulate exocytosis underlying neurite outgrowth through its direct or indirect association with the exocyst complex.
PhysicalDescription
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electronic resource
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x, 122 p. : ill.
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application/pdf
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text/xml
Note
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Ph.D.
Note
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Includes bibliographical references (p. 85-120)
Note
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by Hyun Jong Kim
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Kim
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Hyun Jong
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1972
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author
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Hyun Jong Kim
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Hsu
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Shu
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chair
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Advisory Committee
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Shu C Hsu
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(type = family)
Firestein
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(type = given)
Bonnie
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internal member
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Advisory Committee
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Bonnie L Firestein
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(type = family)
Davis
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Robin
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internal member
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Advisory Committee
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Robin L Davis
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Plummer
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Mark
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internal member
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Advisory Committee
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Mark Plummer
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(ID = NAME-6);
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Zhou
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(type = given)
Renping
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outside member
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Advisory Committee
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Renping Zhou
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
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2009
DateOther
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2009-05
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xx
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NjNbRU
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = doi)
doi:10.7282/T3TX3FK0
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
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Copyright protected
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Open
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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application/x-tar
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4966400
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