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Divergence of AMP synthetic and degradative machinery, and functional implications in psychrophiles
Descriptive
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Text
TitleInfo
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Title
Divergence of AMP synthetic and degradative machinery, and functional implications in psychrophiles
SubTitle
PartName
PartNumber
NonSort
Identifier
ETD_2023
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10005600001.ETD.000051640
Language
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eng
Genre
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theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Psychrophilic bacteria
Abstract
A large group of organisms is well-suited to life at low temperatures (e.g., <20°C, termed psychrophiles) and is therefore able to colonize the majority of earth's biosphere. Interestingly, all observed kingdoms of psychrophiles have been shown to increase concentrations of ATP as temperatures decline; this phenomena has been described as an important compensatory mechanism to deal with decreased thermal energy. In an effort to understand this phenomena, both evolutionarily and metabolically, psychrophilic and mesophilic purine synthesis pathways were examined. Psychrophilic purine synthesis pathways tend to be enriched with de novo AMP synthetic enzymes, while mesophiles tend to be enriched with AMP degradative enzymes. The function of observed psychrophilic pathway structure was tested by engineering the mesophile Escherichia coli to reflect psychrophilic purine synthesis. Mutant E. coli was capable of growing up to 70% faster at low temperatures and became up to 10 fold more cold tolerant relative wild-type. These findings highlight an important evolutionary step in psychrophilic evolution.
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electronic resource
Extent
vii, 58 p. : ill.
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application/pdf
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text/xml
Note
Supplementary File: Table 1
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Supplementary File: Figure1
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Supplementary File: Figure 2
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Supplementary File: Figure 3
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Supplementary File: Figure 4
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Supplementary File: Figure 5
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Supplementary File: Figure 6
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Supplementary File: Figure 7
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Supplementary File: Figure 8
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Supplementary File: Figure 9
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Supplementary File: Figure 10
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references (p. 57-58)
Note
(type = statement of responsibility)
by Bradley R. Parry
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Parry
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Bradley R.
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1984
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author
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Bradley R. Parry
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Shain
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Daniel
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chair
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Advisory Committee
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Daniel H Shain
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McIlroy
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(type = given)
Patrick
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internal member
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Advisory Committee
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Patrick J McIlroy
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(type = family)
Yakoby
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Nir
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internal member
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Advisory Committee
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Nir Yakoby
Name
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Rutgers University
Role
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degree grantor
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Camden Graduate School
Role
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school
OriginInfo
DateCreated
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2009
DateOther
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2009-10
Place
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xx
Location
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NjNbRU
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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(type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier
(type = local)
rucore10005600001
Identifier
(type = doi)
doi:10.7282/T3SB45ZT
Genre
(authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
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Copyright protected
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Open
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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