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PARP inhibitor ABT-888 as potentiating agent for topoisomerase inhibitor SN-38
Descriptive
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Text
TitleInfo
(ID = T-1)
Title
PARP inhibitor ABT-888 as potentiating agent for topoisomerase inhibitor SN-38
Identifier
ETD_1758
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051407
Language
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eng
Genre
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theses
Subject
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(authority = RUETD)
Topic
Microbiology and Molecular Genetics
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
DNA topoisomerases
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
NAD-ADP-ribosyltransferase--Inhibitors
Abstract
BRCA1 is a tumor suppressor gene that has been implicated as being involved in DNA repair through a process known as homologous recombination. Mutations in BRCA 1 have been linked to an increased risk of breast cancer, but recent studies have tried to use their knowledge of homologous recombination in order to find new ways to treat cancer. Most notably with poly(ADP-ribose) polymerase (PARP), it is an enzyme involved in the DNA repair of single strand breaks. If a cell is BRCA1 deficient it cannot repair its double strand breaks and if we inhibit PAR activity the cell cannot repair single strand breaks as a result the cell should accumulate damage and undergo apoptosis and die. The goal of the research is to investigate the role of PAR inhibition in BRCA1 deficient cells. We hypothesized that BRCA1 deficient cells should die at a lower dosage of PAR inhibiting drugs in cytotoxic tests. We also tested the efficiency of cytotoxic therapies as an effective means of treatment and tested the maximum dose tolerable before the cells became changed. We first used immunofluroescence to check for PAR activity in different types of cells and to then see the effects of PAR inhibition. We then used PAR inhibitor ABT-888, topoisomerase inhibitor SN-38, and cisplatin, a DNA binding agent, to conduct cytotoxic tests in order to prove our hypothesis true.
PhysicalDescription
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electronic resource
Extent
vi, 53 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
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Includes bibliographical references (p. 49-53)
Note
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by Honeah Sohail
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Sohail
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Honeah
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1977
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Honeah Sohail
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Ganesan
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Shridar
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chair
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Advisory Committee
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Shridar Ganesan
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Glod
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John
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internal member
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Advisory Committee
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John Glod
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Banerjee
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Debabrata
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internal member
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Advisory Committee
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Debabrata Banerjee
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2009
DateOther
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2009-05
Place
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xx
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
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rucore19991600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T33R0T3W
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
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Open
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Permission or license
Detail
Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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application/x-tar
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1525760
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