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Weight reduction and bone loss in postmenopausal women
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Weight reduction and bone loss in postmenopausal women
SubTitle
follow up at 2 years
Identifier
ETD_1666
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051420
Language
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(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Nutritional Sciences
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Bone densitometry--Health aspects
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Menopause
Subject
(ID = SBJ-1);
(authority = ETD-LCSH)
Topic
Weight loss
Abstract
Short-term weight loss (WL) is accompanied by bone loss in postmenopausal women, but the longer-term impact is unclear. The goal of this study was to determine whether weight regain compared to maintenance of WL in reduced obese/overweight women has an impact on bone mineral density (BMD) and content (BMC). It was hypothesized that weight regain in reduced obese women would result in partial recovery of bone, as compared to women who maintain their lost weight. We measured hip, spine, forearm, and total body BMD and BMC by dual energy x-ray absorptiometry. Hormones, markers of bone turnover, and soft tissue were assessed. We recruited postmenopausal women (n=40, BMI of 28.2 +/- 2.9 kg/m2; 60.6 +/- 5.6 years) 1.5 years after a 6 month weight loss program who were categorized as regaining (>75%) or maintaining their weight lost. After 6 mo of WL, both groups lost -9.1 +/- 3.1% body weight with no significant difference between groups. At 23 +/- 6 mo after baseline, the weight-loss maintainers (WL-M, n=22) and weight-loss re-gainers (WL-R, n=18) lost -10.4 +/- 4.3 % and -2.6 +/- 3.6 % of their body weight. Participants averaged 1228 +/- 529 mg/d during the follow-up period, which did not differ significantly between the groups. The WL-M group showed greater BMD loss at the trochanter (p<0.05), 1/3 radius (p<0.05), and total body (p<0.02) compared with the WL-R group. WL-M also showed a trend to decrease serum osteocalcin (p<0.08) and increase cortisol (p<0.09) more than the WL-R group, as measured in a subset of women (WL-M n=10, WL-R n=8). There were positive relationships between the change in fat mass and 1/3 radius (r=0.047, p<0.01) and total body (r=0.519, p<0.001) in the entire group of women (n=40) while changes at the trochanter and 1/3 radius correlated with leg fat (r>0.422, p<0.01), but not trunk fat, suggesting that regional fat tissue may have a differential influence on bone. These data in postmenopausal women show that bone continues to decline at the trochanter and femoral neck over a 2 year period with 10% weight loss, and with weight regain there is partial recovery of bone.
PhysicalDescription
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electronic resource
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v, 49 p. : ill.
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application/pdf
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Note
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M.S.
Note
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Includes bibliographical references (p. 42-49)
Note
(type = statement of responsibility)
by Nancy L. von Thun
Name
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(type = personal)
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von Thun
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Nancy L.
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1977
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author
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Nancy L. von Thun
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(type = family)
Shapses
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(type = given)
Sue
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chair
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Advisory Committee
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Sue A Shapses
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(type = family)
Igal
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(type = given)
R
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internal member
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Advisory Committee
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R Ariel Igal
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(type = family)
Watford
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Malcolm
Role
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internal member
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Advisory Committee
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Malcolm Watford
Name
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NamePart
Rutgers University
Role
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(type = )
degree grantor
Name
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated
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2009
DateOther
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2009-05
Place
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xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3057G42
Genre
(authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
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Copyright protected
Availability
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Open
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Non-exclusive ETD license
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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application/pdf
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901120
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