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A new, 3D overlapping-sphere model of cell adhesion

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Text
TitleInfo (ID = T-1)
Title
A new, 3D overlapping-sphere model of cell adhesion
SubTitle
PartName
PartNumber
NonSort
Identifier (displayLabel = ); (invalid = )
ETD_2047
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051808
Language (objectPart = )
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eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Biomedical Engineering
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Cell adhesion
Abstract
Cell adhesion refers to the ability of cells to make enduring and dynamic attachments to extracellular surfaces and to each other; rightly so it is a focal point of current biological research. I have designed a computational framework to model cell adhesion using a modified overlapping-sphere model. A core feature of the model is the three-dimensional representation of a cell surface that can interact mechanically with its environment. The generalization of a cell as a sphere gives our model the compactness to enable the simulations of thousands of cells, comparable to the number of cells typically encountered through small scale studies of early development and disease. Specifically, we use this computational framework to model adhesion between cells in a monolayer and a fibrous environment, cell shape change, as well as cell replication. We also include elements of cell orientation, or cell polarity, and touch on some aspects of mechanical feedback. We explore some general aspects of developmental biology as well as cancer in mammary ducts. Although we emphasize epithelial cells, which are cells that form monolayers, we also briefly consider migratory cells. The major results are that (1) Cells in a monolayer, like sheets and tubes, need to be both mobile and well-connected to adapt to mechanically stresses, (2) Cells that are not polarized do not produce a stable monolayer of cells, (3) Extracellular support, like a basement membrane, can minimize the stresses experienced at cell-cell junctions, (4) Mitosis triggered by tension can help maintain a monolayer of cells, (5) Cell shape needs to be incorporated into models to minimize undesirable stresses, (6) Our computational framework is useful to predict behavior of cells subjected to mechanical forces. As this is a new model, results are chiefly qualitative, and suggest future work in collaboration with experimentalists to verify and quantitate our results.
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electronic resource
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ix, 81 p. : ill.
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M.S.
Note (type = bibliography)
Includes bibliographical references (p. 79-81)
Note (type = statement of responsibility)
by Mehdi Doumi
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Doumi
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Mehdi
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1985-
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author
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Mehdi Doumi
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Shinbrot
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Troy
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chair
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Troy Shinbrot
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Shreiber
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David
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internal member
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David Shreiber
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Craelius
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William
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internal member
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William Craelius
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Shvartsman
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Stanislav
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outside member
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Advisory Committee
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Stanislav Shvartsman
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NamePart
Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2009
DateOther (qualifier = exact); (type = degree)
2009-10
Place
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xx
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3XD11VM
Genre (authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work
Copyright
Status
Copyright protected
Notice
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Availability
Status
Open
Reason
Permission or license
Note
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Doumi
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Mehdi
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DateTime
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Mehdi Doumi
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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application/pdf
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application/x-tar
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