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Methods for analyzing deformation of in vitro tissue models during simulated acupuncture therapy

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Text
TitleInfo (ID = T-1)
Title
Methods for analyzing deformation of in vitro tissue models during simulated acupuncture therapy
SubTitle
PartName
PartNumber
NonSort
Identifier (displayLabel = ); (invalid = )
ETD_1998
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000051815
Language (objectPart = )
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Biomedical Engineering
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Acupuncture
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Manipulation (Therapeutics)
Abstract
Traditional acupuncture therapy involves insertion and manipulation of fine needles through the skin at various points of the body. Studying acupuncture therapy both in vivo and ex vivo has revealed that during needle manipulation, loose connective tissue under the skin couples and winds to the needle, producing profound deformation that could act as a mechanism for the treatment’s therapeutic benefits. In order to study this biophysical phenomenon in a controlled setting, we have constructed a simplified model of acupuncture therapy in vitro. We believe that using connective tissue models in our assay allows unique observations not permitted in previous investigations of acupuncture
therapy. Two specific goals of our in vitro assay of acupuncture therapy are: 1) Quantitatively measure the relationship between tissue parameters and the ability to respond to acupuncture therapy, and 2) Make direct observations of deformation invoked by needle manipulation. The objective of this thesis was to construct quantitative tools that allow us to perform these desired observations. We utilize various microscopy and images processing tools to extract quantitative data from our system, including polarized
light microscopy (PLM) to assess aligning extracellular matrix fibers in deforming tissue and automated tracking of displacing beads suspended within our tissue models to characterize the deformation during simulated acupuncture therapy. Our system and the
tools developed for this thesis demonstrate accuracy by corroborating with previously published research and precision by producing reliable, consistent results. These tools have allowed us to make several observations of the biophysical behavior of tissue
during acupuncture therapy and the role of mechanostructural properties in the tissue’s ability to respond to needle manipulation. In conjunction with in vivo and ex vivo research endeavors, we believe that our in vitro tools provide valuable insight towards investigating the role of tissue deformation as a mechanism for acupuncture therapy.
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electronic resource
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vii, 32 p. : ill.
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M.S.
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Includes bibliographical references (p. 31-32)
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by Lowell Taylor Edgar
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Edgar
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Lowell Taylor
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1983-
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Lowell Taylor Edgar
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Shreiber
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David
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chair
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David Shreiber
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Buettner
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Helen
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internal member
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Advisory Committee
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Helen Buettner
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Shinbrot
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Troy
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internal member
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Advisory Committee
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Troy Shinbrot
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
Role
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school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2009
DateOther (qualifier = exact); (type = degree)
2009-10
Place
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xx
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/T3TM7B84
Genre (authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work
Copyright
Status
Copyright protected
Notice
Note
Availability
Status
Open
Reason
Permission or license
Note
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Name
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Edgar
GivenName
Lowell
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DateTime
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Name
Lowell Edgar
Affiliation
Rutgers University. Graduate School - New Brunswick
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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