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Mechanisms of amygdala facilitated cortico-striatal plasticity

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TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Mechanisms of amygdala facilitated cortico-striatal plasticity
SubTitle
PartName
PartNumber
NonSort
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ETD_2204
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10002600001.ETD.000052191
Language (objectPart = )
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eng
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theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Integrative Neuroscience
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Amygdaloid body
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Learning
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
Memory
Abstract
The amygdala is known to mediate the enhancing effects of emotional arousal on learning and memory. The increased firing rate of neurons in the basolateral complex of the amygdala (BLA) is believed to facilitate memory storage in various target structures, such as the striatum. Changes in the efficacy of cortical inputs to the striatum are thought to underlie motor learning and habit formation, making this pathway a perfect model to test the effects of BLA activity on synaptic plasticity and learning. My thesis provides evidence that BLA synapses have an N-methyl-D-aspartate receptor – to α-amino-5-hydroxy-3-methyl-4-isoxazole propionic acid receptor ratio higher than that of cortical synapses onto the same striatal neurons (Chapter 3). This property allows BLA inputs to facilitate the induction of heterosynaptic long term potentiation in vitro (Chapters 4 and 5). I also show that temporal coupling of BLA and striatal neurons in vivo occurs during coherent bursts of gamma activity observed in the local field potentials. Changes in the coherence of BLA-striatal gamma paralleled learning of a striatal-dependent task (Chapter 6). Together, these findings point towards a new mechanism of amygdala-facilitated learning.
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electronic resource
Extent
ix, 132 p. : ill.
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Supplementary File: Figure 31
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references (p. 111-123)
Note (type = statement of responsibility)
by Andrei Tiberiu Popescu
Name (ID = NAME-1); (type = personal)
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Popescu
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Andrei Tiberiu
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Andrei Tiberiu Popescu
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James
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chair
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Advisory Committee
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James M Tepper
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Krekelberg
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Bart
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Bart Krekelberg
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Nadim
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Farzan
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Farzan Nadim
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Lovinger
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David
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outside member
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Advisory Committee
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David M Lovinger
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Rutgers University
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degree grantor
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Graduate School - Newark
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school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2010
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2010-01
Place
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xx
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - Newark Electronic Theses and Dissertations
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rucore10002600001
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Identifier (type = doi)
doi:10.7282/T39W0FNR
Genre (authority = ExL-Esploro)
ETD doctoral
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The author owns the copyright to this work.
Copyright
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Copyright protected
Notice
Note
Availability
Status
Open
Reason
Permission or license
Note
RightsHolder (ID = PRH-1); (type = personal)
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Popescu
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Andrei
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Place
DateTime
2009-12-04 01:24:56
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Name
Andrei Popescu
Affiliation
Rutgers University. Graduate School - Newark
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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