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Depressive symptomatology, hippocampal volume, and contextual memory in late life generalized anxiety disorder
Descriptive
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Text
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Title
Depressive symptomatology, hippocampal volume, and contextual memory in late life generalized anxiety disorder
SubTitle
an MRI study
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PartNumber
NonSort
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ETD_2303
Identifier
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052099
Language
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eng
Genre
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theses
Subject
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Topic
Psychology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Depression, Mental
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Memory
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Depression in old age
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Abstract
Research has shown that reductions in hippocampal volume can result from various forms of stress and are a feature of Major depressive disorder (MDD), with some studies suggesting similar impairments in PTSD. However, there has been little research on the connection between stress and the hippocampus as it relates to other affective and anxiety disorders. The current study examined hippocampal morphology and functioning and their relationship to depressive symptomatology in older adults with Generalized anxiety disorder (GAD). We hypothesized that GAD patients may show lower hippocampal volume and functioning; and having GAD might add to or magnify the impact of depression on the hippocampus. Participants were 15 older adults diagnosed with GAD without co-occurring MDD, and 15 age- and sex-matched non-anxious controls. Participants completed a diagnostic interview; measures of anxiety and depression; neuropsychological tests; and a structural MRI scan. The Verbal Paired Associates (VPA) test (Wechsler, 1997) was used to assess verbal contextual memory, a common index of hippocampal functioning. Higher levels of depressive symptomatology, as measured by the Beck Depression Inventory (Beck & Steer, 1987), were associated with smaller hippocampal volumes, which were in turn associated with lower scores on VPA recall and on the Stroop color test (StroopC; Trenerry, Crosson, DeBoe, & Leber, 1989). The association between depression and the hippocampus was significantly stronger in the GAD sample. In addition, reductions in hippocampal volume and VPA delayed recall and StroopC scores were found in those GAD patients with the highest levels of depression (n = 5), after controlling for several covariates. Findings suggest that alterations in hippocampal morphology and functioning may be evident in a subset of GAD patients, specifically those with higher levels of depression. They also support the idea that, in the context of GAD, even moderate levels of depression that fail to meet diagnostic criteria for MDD may have deleterious effects on the brain and mind. Implications for the conceptualization and treatment of GAD are discussed.
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electronic resource
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vi, 54 p. : ill.
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M.S.
Note
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Includes bibliographical references (p. 49-53)
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by Daniel Chazin
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Chazin
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Daniel
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Daniel Chazin
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Mohlman
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Jan
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chair
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Advisory Committee
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Jan Mohlman
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Karlin
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Robert
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internal member
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Advisory Committee
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Robert Karlin
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Contrada
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Richard
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Advisory Committee
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Richard Contrada
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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OriginInfo
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2010
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2010-01
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T3M908V9
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
Copyright
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Copyright protected
Notice
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Availability
Status
Open
Reason
Permission or license
Note
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Name
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Chazin
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Daniel
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Place
DateTime
2009-12-15 06:36:50
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Daniel Chazin
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Rutgers University. Graduate School - New Brunswick
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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471040
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