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Genome-wide expression analysis implicates working memory associated genes in the general learning abilities of outbred mice
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Title
Genome-wide expression analysis implicates working memory associated genes in the general learning abilities of outbred mice
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ETD_2258
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052119
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eng
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theses
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Topic
Psychology
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(authority = ETD-LCSH)
Topic
Memory--Genetic aspects
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(authority = ETD-LCSH)
Topic
Learning ability
Abstract
Previously, we have reported the existence of a general learning factor in genetically heterogeneous mice, and this factor is in many ways analogous to general intelligence in humans. This previous work established that the processes underlying general learning abilities in mice are, as in humans, related to working memory capacity and specifically selective attention. In the present set of experiments, using gene-expression microarray technology that allowed us to quantify the expression of ~25,000 genes simultaneously, we assessed the gene expression profiles of the best and worst learners from a sample of 60 mice (in two replications). For each group we compared four different brain regions (prefrontal cortex, the remaining cortex, cerebellum and hippocampus). The most consistent pattern of differential expression was found in the prefrontal cortex, here a set of genes associated with the efficacy of dopamine functioning (i.e., Drd1a, Darpp-32, Rgs9) were upregulated in the fastest learners. As prefrontal dopamine functioning is associated with working memory, these results dove-tail with our previous behavioral results that demonstrated a relationship between working memory capacity and general learning abilities. This relationship was further verified through a quantitative PCR analysis where we demonstrated a significant correlation between the expression of these prefrontal dopamine genes and the general learning abilities of 48 mice. In total these results suggest that working memory and specifically dopamine signaling efficacy in the prefrontal cortex may be crucial for the establishment of general learning abilities.
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electronic resource
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vii, 61 p. : ill.
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Ph.D.
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Includes bibliographical references (p. 39-44)
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by Stefan Matthew Kolata
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Kolata
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Stefan Matthew
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Stefan Matthew Kolata
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Matzel
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Louis
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chair
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Louis D Matzel
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Otto
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Timothy
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internal member
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Timothy Otto
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Kusnecov
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Alexander
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Alexander Kusnecov
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Shumyatsky
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Gleb Shumyatsky
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Rutgers University
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Graduate School - New Brunswick
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school
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2010
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2010-01
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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doi:10.7282/T3668DCZ
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ETD doctoral
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Rights
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Notice
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Availability
Status
Open
Reason
Permission or license
Note
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Kolata
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Stefan
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DateTime
2009-11-19 16:47:31
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Stefan Kolata
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Rutgers University. Graduate School - New Brunswick
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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