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Positive feedback regulation of wishful thinking shapes bone morphogenetic protein signaling in the follicular epithelium
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Positive feedback regulation of wishful thinking shapes bone morphogenetic protein signaling in the follicular epithelium
Identifier
ETD_2662
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10005600001.ETD.000052814
Language
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(type = code)
English
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Drosophila melanogaster
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Bone morphogenetic proteins
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Oogenesis
Abstract
Morphogenesis is preceded by an extensive gene patterning that is regulated by a small number of signaling pathways. One such pathway, the Bone Morphogenetic Protein (BMP) pathway, is an essential developmental regulator in many organisms throughout Eukarya, including Drosophila melanogaster. An established system to study patterning that is regulated by cell-to-cell signaling is D. melanogaster oogenesis. A two-dimensional monolayer of follicle cells (FCs) surrounds the developing oocyte, becomes patterned and later folds into eggshell structures; this process is regulated, in part, by BMP signaling. While BMP signaling in the FCs is associated with the patterning of the type I receptor, thickveins (tkv), the cooperating type II receptor remains unknown. Here, I aimed to establish its identity. Though previously only reported during embryonic neurogenesis, I found that the type II receptor, wishful thinking (wit), is expressed in an evolutionary conserved pattern in the FCs of species that diverged over 45 million years. Also, WIT is self-regulated by a positive feedback loop, which I demonstrate works to sharpen the BMP signaling gradient. Of importance, null clones of WIT coincide with a cell autonomous loss of BMP signaling, monitored by the phosphorylated form of the intercellular signaling molecule MAD (P-MAD). Loss of WIT has changes the patterning of Broad, a marker for dorsal appendages, affecting eggshell morphology. These results demonstrate an active role for WIT in non-neuronal tissue, and establish WIT as the type II receptor working in concert with TKV during FC patterning.
PhysicalDescription
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electronic resource
Extent
viii, 35 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references (p. 16-20)
Note
(type = statement of responsibility)
by Robert Marmion
Note
Includes abstract
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Marmion
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Robert
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1985-
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author
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Robert Marmion
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(type = family)
Yakoby
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Nir
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chair
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Advisory Committee
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Nir Yakoby
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NamePart
(type = family)
Shain
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(type = given)
Daniel H.
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internal member
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Advisory Committee
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Daniel H. Shain
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Lee
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(type = given)
Kwangwon
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internal member
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Advisory Committee
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Kwangwon Lee
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NamePart
Rutgers University
Role
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degree grantor
Name
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NamePart
Camden Graduate School
Role
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(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010-05
Place
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(type = code)
xx
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier
(type = local)
rucore10005600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T37D2V7N
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
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(type = personal)
Name
FamilyName
Marmion
GivenName
Robert
Role
Copyright Holder
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Type
Permission or license
DateTime
2010-05-10 10:29:39
AssociatedEntity
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(AUTHORITY = rulib)
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Copyright holder
Name
Robert Marmion
Affiliation
Rutgers University. Camden Graduate School
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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ETD
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application/pdf
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application/x-tar
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931840
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