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Systematic analysis of bone morphogenetic protein signal diversification across Drosophila species during oogenesis
Descriptive
TypeOfResource
Text
TitleInfo
Title
Systematic analysis of bone morphogenetic protein signal diversification across Drosophila species during oogenesis
Identifier
ETD_2714
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10005600001.ETD.000052815
Identifier
(type = doi)
doi:10.7282/T3C53KXH
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
English
Genre
(authority = marcgt)
theses
Genre
(authority = marcgt)
bibliography
Genre
(authority = ExL-Esploro)
ETD graduate
Subject
(authority = ETD-LCSH)
Topic
Drosophila
Subject
(authority = ETD-LCSH)
Topic
Oogenesis
Subject
(authority = ETD-LCSH)
Topic
Drosophila--Morphology
Subject
(authority = ETD-LCSH)
Topic
Bone morphogenetic proteins
Abstract
Eggshells of Drosophila species provide great examples of morphological variation. The eggshell is a three-dimensional structure that protects the developing embryo from the surrounding environment and allows continuous gas exchange via tube-like structures called dorsal appendages (DAs). The number, size, shape, and positions of DAs vary among Drosophila species. During animal development, a handful of signaling pathways control tissue differentiation and morphogenesis. In general, mechanisms governing signal diversification that guide morphological variation remain largely unexplored. One conserved signaling pathway involved in guiding tissue development during Drosophila oogenesis is the Bone Morphogenetic Protein (BMP) signaling pathway. Representing a variety of eggshell morphologies, 16 Drosophila species were screened for diversity in BMP signaling during oogenesis. During early oogenesis, BMP signaling in all species was maintained in similar patterns displaying only anterior-posterior polarity. However, BMP signaling during late oogenesis acquired patterns with distinct dorsal-ventral polarities in all species. Further analyses of late patterns revealed five unique patterning groups. Using genetic tools, we demonstrated that the BMP type I receptor thickveins (tkv) accounted for BMP signaling diversification. Based on signaling diversity, computational modeling was employed to predict patterns of tkv that were further tested experimentally. For most species, it was concluded that spatial changes to tkv guided diversification of late BMP signaling. In species belonging to the D. virilis-repleta radiation, tkv partially accounted for BMP signaling diversity and, for that radiation, the model proposes the involvement of another receptor in guiding BMP signaling. These results establish tkv as a major component in regulating BMP signaling diversification across 45 million years of evolution.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
ix, 47 p. : ill.
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application/pdf
InternetMediaType
text/xml
Note
(type = degree)
M.S.
Note
(type = bibliography)
includes bibliographical references (p. 18-21)
Note
(type = statement of responsibility)
by Matthew Gene Niepielko
Note
Includes abstract
Name
(type = personal)
NamePart
(type = family)
Niepielko
NamePart
(type = given)
Matthew Gene
NamePart
(type = date)
1985-
Role
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(authority = RULIB)
author
DisplayForm
Matthew Niepielko
Name
(type = personal)
NamePart
(type = family)
Yakoby
NamePart
(type = given)
Nir
Role
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(authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Nir Yakoby
Name
(type = personal)
NamePart
(type = family)
Shain
NamePart
(type = given)
Daniel H.
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Daniel H. Shain
Name
(type = personal)
NamePart
(type = family)
Saidel
NamePart
(type = given)
William M.
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
William M. Saidel
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Camden Graduate School
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010-05
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
Identifier
(type = local)
rucore10005600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Subject
(authority = RUETD)
Topic
Biology
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Niepielko
GivenName
Matthew
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-05-10 11:21:28
AssociatedEntity
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(AUTHORITY = rulib)
Role
Copyright holder
Name
Matthew Niepielko
Affiliation
Rutgers University. Camden Graduate School
AssociatedObject
(ID = AO-1);
(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
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(TYPE = container)
application/x-tar
FileSize
(UNIT = bytes)
2222080
Checksum
(METHOD = SHA1)
04ddcb2742452ecde57c23d3e55a16ba1649c78d
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