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Biomimetic enzyme inhibitors
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Biomimetic enzyme inhibitors
Identifier
ETD_2451
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052972
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Biomimetics
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Enzyme inhibitors
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Organoselenium compounds
Abstract
(type = abstract)
Synthetic biomimetic compounds play crucial roles in virtually all aspects of biology and medicine. Their continual development contributes towards understanding and manipulating the normal action of enzymes and other proteins as well as in the development of new drugs. Herein, the novel synthesis of biomimetic enzyme inhibitors, including GlcNAc-thiazolines, GlcNAc-thiolsulfonates, and seleninates, selenonates, and various other organoselenium compounds, is reported. Evaluation of these biomimetics against N-acetyl-β-hexosaminidases, protein tyrosine phosphatases, and some nucleoside processing enzymes is described. Evidence toward elucidation of several reaction mechanisms linked to the synthesis and inhibition of these compounds is also presented.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
xxi, 452 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
(type = degree)
Ph.D.
Note
Includes abstract
Note
Vita
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Mohannad Abdo
Name
(ID = NAME-1);
(type = personal)
NamePart
(type = family)
Abdo
NamePart
(type = given)
Mohannad
NamePart
(type = date)
1983-
Role
RoleTerm
(authority = RULIB)
author
DisplayForm
Mohannad Abdo
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Knapp
NamePart
(type = given)
Spencer
Role
RoleTerm
(authority = RULIB)
chair
Affiliation
Advisory Committee
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Spencer Knapp
Name
(ID = NAME-3);
(type = personal)
NamePart
(type = family)
Roth
NamePart
(type = given)
Heinz D
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Heinz D Roth
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Seidel
NamePart
(type = given)
Daniel
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Daniel Seidel
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
Amorelli
NamePart
(type = given)
Benjamin
Role
RoleTerm
(authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Benjamin Amorelli
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3BK1CDC
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Abdo
GivenName
Mohannad
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-02-03 11:54:14
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Mohannad Abdo
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
(ID = AO-1);
(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
MimeType
(TYPE = container)
application/x-tar
FileSize
(UNIT = bytes)
14858240
Checksum
(METHOD = SHA1)
60ad00756ffe30a18c9fb22e7fb7be72401e7cf4
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Statistical Profile