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Sirtuin 1 (SIRT1) regulates the HSF-1-dependent pro-survival mechanism in neurons
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Sirtuin 1 (SIRT1) regulates the HSF-1-dependent pro-survival mechanism in neurons
Identifier
ETD_2615
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000053118
Language
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(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Cell and Developmental Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Heat shock proteins
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Nervous system--Degeneration
Abstract
(type = abstract)
The heat shock response (HSR) provides cytoprotection against protein misfolding and aggregation, characteristic of neurodegenerative diseases. Unfortunately, neurons have a diminished ability to mount this HSR. Understanding the molecular mechanism that limits the activation of heat shock transcription factor 1 (HSF1) is imperative for the development of neurodegenerative disease therapeutics. This thesis provides evidence that SIRT1, a histone deacetylase is required for the activation and stability of HSF1. Our results showed that decreased expression of Sirt1 is a feature of differentiating neural progenitor cells and maturing neurons. In addition, we showed decreased Sirt1 expression results in a decreased amount and activity of HSF1, which contributes to an attenuated HSR. Understanding the regulation and function of HSF1 in neuronal cells, and will expedite advancements in therapeutics development to harness the HSF1-dependent pro-survival mechanism to mitigate disease processes of neurons.
PhysicalDescription
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electronic resource
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vi, 51 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
Includes abstract
Note
(type = bibliography)
Includes bibliographical references
Name
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Liu
NamePart
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Diana J.
NamePart
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1985-
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author
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Diana Liu
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Liu
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Alice YC
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chair
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Advisory Committee
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Alice YC Liu
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(type = family)
Zarbl
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(type = given)
Helmut
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internal member
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Advisory Committee
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Helmut Zarbl
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(type = personal)
NamePart
(type = family)
Fong
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(type = given)
Dunne
Role
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(authority = RULIB)
internal member
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Advisory Committee
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Dunne Fong
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
OriginInfo
DateCreated
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2010
DateOther
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2010
Place
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xx
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
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(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = doi)
doi:10.7282/T30K28P0
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
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(type = personal)
Name
FamilyName
Liu
GivenName
Diana
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-04-15 00:19:24
AssociatedEntity
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Copyright holder
Name
Diana Liu
Affiliation
Rutgers University. Graduate School - New Brunswick
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(AUTHORITY = rulib)
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
(ID = RE-2);
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Type
Embargo
DateTime
2010-05-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after November 30th, 2010.
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Technical
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ETD
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application/pdf
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application/x-tar
FileSize
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1863680
Checksum
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