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The prefrontal cortex communicates with the amygdala to impair learning after an acute stressful experience in females
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
The prefrontal cortex communicates with the amygdala to impair learning after an acute stressful experience in females
Identifier
ETD_2529
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000053120
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Psychology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Brain--Effect of stress on
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Stress (Psychology)
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Women--Health and hygiene
Subject
(ID = SBJ-5);
(authority = ETD-LCSH)
Topic
Learning, Psychology of
Abstract
(type = abstract)
Exposure to an acute stressful event enhances classical eyeblink conditioning in male rats, whereas exposure to the same event dramatically impairs performance in females (Wood & Shors, 1998; Wood et al., 2001). We hypothesized that stress affects learning differently in males and females because different brain regions and circuits are being activated. In the first experiment, we determined that neuronal activity within the medial prefrontal cortex (mPFC) during the stressful event is necessary to disrupt learning in females. In both males and females, the mPFC was bilaterally inactivated with GABA agonist muscimol prior to the stressor. Inactivation only prevented the impaired performance in females; it had no consequence for performance in males. Previous studies indicate that neuronal activity within the basolateral amygdala (BLA) during the stressful event is necessary for the impaired performance in females (Waddell et al., 2008). In the second experiment, we hypothesized that the mPFC communicates with the BLA to disrupt learning in females after the stressor. To test this hypothesis, these structures were disconnected from each other with unilateral excitotoxic (NMDA) lesions on either the same or opposite sides of the brain. Females with contralateral lesions, which disrupt the connections on both sides of the brain, were able to learn after the stressful event, whereas those with ipsilateral lesions, which disrupt only one connection, did not learn after the stressor. Together, these data indicate that the mPFC is preferentially engaged in females during stress to impair subsequent learning and does so via communication with the amygdala.
PhysicalDescription
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electronic resource
Extent
vi, 33 p. : ill.
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application/pdf
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text/xml
Note
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M.S.
Note
Includes abstract
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Lisa Y. Maeng
Name
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(type = personal)
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Maeng
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(type = given)
Lisa Y.
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1983-
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author
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Lisa Maeng
Name
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(type = personal)
NamePart
(type = family)
Shors
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(type = given)
Tracey J
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chair
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Advisory Committee
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Tracey J Shors
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(type = personal)
NamePart
(type = family)
Otto
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(type = given)
Tim
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internal member
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Advisory Committee
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Tim Otto
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West
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(type = given)
Mark
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internal member
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Advisory Committee
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Mark West
Name
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NamePart
Rutgers University
Role
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degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010
Place
PlaceTerm
(type = code)
xx
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3833S3M
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
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(type = personal)
Name
FamilyName
Maeng
GivenName
Lisa
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-04-06 01:37:17
AssociatedEntity
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(AUTHORITY = rulib)
Role
Copyright holder
Name
Lisa Maeng
Affiliation
Rutgers University. Graduate School - New Brunswick
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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ETD
MimeType
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application/pdf
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application/x-tar
FileSize
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819200
Checksum
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