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Trends in cancer and development of AIDS in HIV-infected individuals before and after implementation of highly active antiretroviral therapy

Descriptive

TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Trends in cancer and development of AIDS in HIV-infected individuals before and after implementation of highly active antiretroviral therapy
Identifier
ETD_2504
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000053121
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Public Health
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
AIDS malignancies
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
AIDS (Disease)--Patients
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
HIV-positive persons--Cancer
Subject (ID = SBJ-5); (authority = ETD-LCSH)
Topic
Highly active antiretroviral therapy
Abstract (type = abstract)
Research Objectives --To analyze the effect of highly active anti-retroviral therapy on cancer incidence and mean age at cancer diagnosis in HIV-infected persons; on progression to AIDS related to cancer; and risks of cancer, pre- and post-HAART. Methods --Records on New Jersey HIV-infected residents were used for a retrospective cohort study of HIV and cancer. Lung, colorectal, prostate, Hodgkin lymphoma, and anal cancer were studied. Incidence density pre- and post-HAART was tested for change in Standardized Incidence Ratio (SIRs). Relative risk was approximated by the ratio of the SIRs from the two periods. Difference in mean age at diagnosis pre- and post-HAART for each type was tested by a Student’s t. Risks of developing AIDS, pre- and post-HAART in HIV-infected persons with and without a cancer diagnosis were evaluated through proportional hazards regression. Cox Proportional Regression was used to assess the hazard ratios associated with cancer after HIV seroconversion in the two periods. Results Cumulative incidence rates increased substantially for prostate cancer, and slightly for anal cancer and Hodgkin lymphoma pre- to post-HAART, but not for lung and colorectal cancer. Cumulative incidence rates for HIV-infected persons observed only pre- HAART were lower when compared to those HIV-positive only post-HAART for all five studied cancer types. SIRs were significant for all but pre-HAART colorectal cancer. Relative risks post-HAART compared to pre-HAART for each of the cancers, other than Hodgkin lymphoma, were significantly low. Age-specific incidence rates post-HAART were higher in the oldest age groups for colorectal and prostate cancer in addition to Hodgkin disease, but decreased in every age group for lung cancer. Mean age at cancer diagnosis was significantly higher in the post-HAART period for lung and colorectal cancer and Hodgkin lymphoma, but unchanged for prostate cancer. The regression analysis indicated an increased risk of AIDS development if a cancer was diagnosed after HIV seroconversion, but before AIDS, although the risk decreased post-HAART. The hazard ratio for cancer development was not significantly different pre- and post-HAART. Conclusions --HAART availability and an increase in survival have significantly changed trends in HIV infection and associated morbidity, particularly for cancer in HIV-infected persons.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
viii, 109 p. : ill.
InternetMediaType
application/pdf
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text/xml
Note (type = degree)
Ph.D.
Note
Includes abstract
Note
Vita
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Rose Marie Martin
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Martin
NamePart (type = given)
Rose Marie
Role
RoleTerm (authority = RULIB)
author
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Rose Martin
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
DEMISSIE
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KITAW
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chair
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Advisory Committee
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KITAW DEMISSIE
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Fulcomer
NamePart (type = given)
Mark C.
Role
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internal member
Affiliation
Advisory Committee
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Mark C. Fulcomer
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Lu
NamePart (type = given)
Shou-En
Role
RoleTerm (authority = RULIB)
internal member
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Advisory Committee
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Shou-En Lu
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Paul
NamePart (type = given)
Sindy M.
Role
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internal member
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Advisory Committee
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Sindy M. Paul
Name (ID = NAME-6); (type = personal)
NamePart (type = family)
August
NamePart (type = given)
David
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
David August
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2010
DateOther (qualifier = exact); (type = degree)
2010
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T3CV4HTM
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = PRH-1); (type = personal)
Name
FamilyName
Martin
GivenName
Rose
Role
Copyright Holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-03-23 15:41:54
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Copyright holder
Name
Rose Martin
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

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ETD
MimeType (TYPE = file)
application/pdf
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application/x-tar
FileSize (UNIT = bytes)
829440
Checksum (METHOD = SHA1)
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