The design of new chiral binuclear ligands was undertaken to address the challenge of catalyzing nucleophilic additions to simple α,β- unsaturated carbonyl compounds. The designs were based on natural bimetallic enzymes as well as on synthetic achiral bimetallic complexes. Ligands with different electronic and structural properties were synthesized and a variety of transition metal complexes prepared. Their catalytic activities were tested in 1,4-additions of indole to α,β-unsaturated carbonyl compounds. Single X-ray crystallography was used to gain an insight into the nature of these newly developed chiral bimetallic complexes. Efforts were made to synthesize chiral bimetallic complexes derived from amino indanol.
A new reaction methodology was investigated to form cyclic aminals from aminobenzaldehydes and secondary amines. The methodology was shown to be successful for broad range of substrates. L-proline could be used in place of secondary amines in a decarboxylative variant of the reaction. The use of microwave irradiation was explored as a means to extend the scope of this methodology.
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electronic resource
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ix, 74 p. : ill.
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application/pdf
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M.S.T.
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Includes abstract
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Includes bibliographical references
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by Rudrajit Mal
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Mal
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Rudajit
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1983-
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Rudajit Mal
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Seidel
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Daniel
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chair
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Daniel Seidel
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Knapp
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Spencer Knapp
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Hultzsch
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Kai
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Kai Hultzsch
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Rutgers University
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Graduate School - New Brunswick
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2010
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2010
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xx
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Rutgers University Electronic Theses and Dissertations
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ETD
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
Identifier (type = doi)
doi:10.7282/T3TH8MSH
Genre (authority = ExL-Esploro)
ETD graduate
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Mal
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Rudajit
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2010-04-13 19:25:35
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Rudajit Mal
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Rutgers University. Graduate School - New Brunswick
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.