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Analytical method development for measurement of unregulated organic contaminants in aqueous samples using liquid chromatography - tandem mass spectrometry

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TypeOfResource
Text
TitleInfo (ID = T-1)
Title
Analytical method development for measurement of unregulated organic contaminants in aqueous samples using liquid chromatography - tandem mass spectrometry
Identifier
ETD_2593
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000053570
Language
LanguageTerm (authority = ISO639-2); (type = code)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Environmental Sciences
Subject (ID = SBJ-2); (authority = ETD-LCSH)
Topic
Liquid chromatography
Subject (ID = SBJ-3); (authority = ETD-LCSH)
Topic
Mass spectrometry
Subject (ID = SBJ-4); (authority = ETD-LCSH)
Topic
Chemistry, Analytic
Subject (ID = SBJ-5); (authority = ETD-LCSH)
Topic
Environmental sciences
Abstract (type = abstract)
Organic wastewater contaminants (OWCs) such as pharmaceuticals, hormones, and perfluorinated compounds (PFCs) are of growing environmental and public health concern. These OWCs were found in U.S. drinking water supplies according to nationwide studies by the U.S. Geological Survey. Many OWCs are not, however, regulated or routinely monitored in drinking water. The objective of this dissertation was to develop and optimize analytical methods for trace analysis of unregulated organic contaminants in drinking water sources. Furthermore, household water treatment-processes were studied to measure the efficacy of removal of these unregulated organic contaminants from drinking water samples. Two liquid chromatography-ion trap mass spectrometry systems (LC-IT-MS/MS) were compared for rapid, reliable and sensitive detection of the most abundant PFCs, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). An ultra performance LC-linear IT-MS/MS achieved the lowest detection limits measured, 0.03pg and 0.24pg for PFOA and PFOS respectively, which were approximately two orders of magnitude more sensitive than an LC-IT-MS/MS. With the increased sensitivity, the direct analysis of PFOA/S without solid phase extraction pre-concentration steps was also demonstrated. In addition, MS methods using Full Scan, Single Ion Monitoring, and MS/MS were compared and optimized for a sensitive analysis of PFCs. A novel rapid method was created by switching polarity for the simultaneous analysis of twenty unregulated compounds, including pharmaceuticals. Sensitive method detection limits were achieved in the range of sub ng/L to hundreds ng/L for all target compounds. An optimized analytical method was applied to quantify low ng/L levels of these target compounds in field water samples from regions throughout New Jersey. Eight target compounds were measured below 1µg/L and two target compounds (i.e. metformin and estradiol) were measured slightly above 1µg/L in the field water samples. Finally, granular activated carbon (GAC) and ion resin (Brita™) filtration, ozonation, and microwave heating were tested for efficacy at removing 20 target compounds in drinking water samples. The GAC/ion resin mechanism with adsorption properties demonstrated greater removal of the target compounds than the other two mechanisms. Even this water treatment-process only partially removed these target compounds with its mean removal of ≤ 66%.
PhysicalDescription
Form (authority = gmd)
electronic resource
Extent
xi, 164 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note (type = degree)
Ph.D.
Note
Includes abstract
Note
Vita
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Min K. Yoon
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Yoon
NamePart (type = given)
Min
NamePart (type = date)
1982-
Role
RoleTerm (authority = RULIB)
author
DisplayForm
Min Yoon
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
Buckley
NamePart (type = given)
Brian T
Role
RoleTerm (authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Brian T Buckley
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Strom
NamePart (type = given)
Peter F
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Peter F Strom
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Robson
NamePart (type = given)
Mark G
Role
RoleTerm (authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Mark G Robson
Name (ID = NAME-5); (type = personal)
NamePart (type = family)
Lippincott
NamePart (type = given)
Lee R
Role
RoleTerm (authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Lee R Lippincott
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB)
school
OriginInfo
DateCreated (qualifier = exact)
2010
DateOther (qualifier = exact); (type = degree)
2010
Place
PlaceTerm (type = code)
xx
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/T30C4VTH
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (AUTHORITY = GS); (ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = PRH-1); (type = personal)
Name
FamilyName
Yoon
GivenName
Min
Role
Copyright Holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-04-14 14:30:41
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Copyright holder
Name
Min Yoon
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical

ContentModel
ETD
MimeType (TYPE = file)
application/pdf
MimeType (TYPE = container)
application/x-tar
FileSize (UNIT = bytes)
1331200
Checksum (METHOD = SHA1)
3efc2334c5fe13b5a00f84c90ea51f1fae57dde0
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