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Prozac and puberty
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
Prozac and puberty
SubTitle
the effects of fluoxetine treatment on neurogenesis in the pubescent hippocampus
Identifier
ETD_196
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000054798
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Psychology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Fluoxetine--Side effects
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
Subject
(ID = SBJ-4);
(authority = ETD-LCSH)
Topic
Depression in adolescence--Treatment
Abstract
(type = abstract)
Chronic treatment with fluoxetine (Prozac) increases cell proliferation and neurogenesis in the dentate gyrus of the adult male rat (Encinas et al., 2006; Malberg et al., 2000). Therefore neurogenesis was proposed to be a mechanism through which antidepressants alleviate some symptoms of depression (Jacobs et al., 2000; Duman, 2004a; Sapolsky, 2004). Here we tested whether chronic fluoxetine treatment increases cell proliferation and neurogenesis in pubescent and adult female rats. Rats were injected with fluoxetine (5mg/kg) or saline for 14 days. One day later subjects were injected with 5-bromo-2’- deoxyuridine (BrdU; 200mg/ kg), a marker of dividing cells. Rats in experiment 1 were sacrificed 2hrs after BrdU injection to measure cell proliferation. Subjects in experiment 2 were sacrificed at 24 hrs to measure cell proliferation after a full cell cycle. In experiment 3 subjects were sacrificed 28 days after BrdU injection to measure neurogenesis. At all time points fluoxetine increased proliferation and neurogenesis in adult male rats. However, the drug did not alter proliferation or neurogenesis in pubescent males. Proliferation and neurogenesis were elevated during puberty for both sexes, irrespective of treatment. There were no effects of fluoxetine treatment on proliferation or neurogenesis in females at either age, or across the estrous cycle. Immunofluorescent labeling with BrdU and NeuN a marker of mature neurons verified an effect of fluoxetine treatment only in adult male subjects. Double labeling also indicated that cell fate was not altered at any age by treatment. Blood samples were taken to determine whether fluoxetine altered circulating levels of sex and stress hormones 24 hrs or 29 days after treatment. Treatment decreased corticosterone concentrations in pubescent female rats sacrificed at the later time. There were no other hormonal effects of fluoxetine treatment. These data indicate that pubescent rats respond differently to antidepressants than adults. Hormonal changes in the pubescent female seem especially susceptible to the effects of fluoxetine. In addition, fluoxetine may operate differently in adult females than in adult males. Together, these results indicate that antidepressants probably operate via different neuronal mechanisms in adult males than in other age groups or even the other sex.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
viii, 107 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
(type = degree)
Ph.D.
Note
Includes abstract
Note
Vita
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Georgia E. Hodes
Name
(ID = NAME-1);
(type = personal)
NamePart
(type = family)
Hodes
NamePart
(type = given)
Georgia
Role
RoleTerm
(authority = RULIB)
author
DisplayForm
Georgia Hodes
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Shors
NamePart
(type = given)
Tracey J
Role
RoleTerm
(authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Tracey J Shors
Name
(ID = NAME-3);
(type = personal)
NamePart
(type = family)
Gandelman
NamePart
(type = given)
Ronald
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Ronald Gandelman
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Auerbach
NamePart
(type = given)
Sidney B
Role
RoleTerm
(authority = RULIB)
internal member
Affiliation
Advisory Committee
DisplayForm
Sidney B Auerbach
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
DiCicco-Bloom
NamePart
(type = given)
Emanuel
Role
RoleTerm
(authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Emanuel DiCicco-Bloom
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2007
DateOther
(qualifier = exact);
(type = degree)
2007
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3H70FRD
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Hodes
GivenName
Georgia
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2007-04-27 14:52:14
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Georgia Hodes
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
(ID = AO-1);
(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
ContentModel
ETD
MimeType
(TYPE = file)
application/pdf
MimeType
(TYPE = container)
application/x-tar
FileSize
(UNIT = bytes)
501760
Checksum
(METHOD = SHA1)
9d5bbd6133bac4006833ee857cac2ada9d19dd50
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