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Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brainstem

Descriptive

TypeOfResource
Text
TitleInfo
Title
Timing of impulses from the central amygdala and bed nucleus of the stria terminalis to the brainstem
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.1/rucore00000001075.Manuscript.000052733
Identifier (type = doi)
doi:10.7282/T3HT2MM9
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Subject (authority = lcsh)
Topic
Amygdaloid body
Subject (authority = lcsh)
Topic
Anxiety
Subject (authority = lcsh)
Topic
Fear
Abstract (type = abstract)
The amygdala and bed nucleus of the stria terminalis (BNST) are thought to subserve distinct functions with the former mediating rapid fear responses to discrete sensory cues and the latter longer “anxiety-like” states in response to diffuse environmental contingencies. Yet, these structures are reciprocally connected and their projection sites overlap extensively. To shed light on the significance of BNST-amygdala connections, we compared the antidromic response latencies of BNST and central amygdala (CE) neurons to brainstem stimulation. Whereas the frequency distribution of latencies was unimodal in BNST neurons (~10 ms mode), that of CE neurons was bimodal (~10 and ~30 ms modes). However, after stria terminalis (ST) lesions, only short-latency antidromic responses were observed, suggesting that CE axons with long conduction times course through the ST. Compared to the direct route, the ST greatly lengthens the path of CE axons to the brainstem, an apparently disadvantageous arrangement. Since BNST and CE share major excitatory basolateral amygdala (BL) inputs, lengthening the path of CE axons might allow synchronization of BNST and CE impulses to brainstem when activated by BL. To test this, we applied electrical BL stimuli and compared orthodromic response latencies in CE and BNST neurons. The latency difference between CE and BNST neurons to BL stimuli approximated that seen between the antidromic responses of BNST cells and CE neurons with long-conduction times. These results point to a hitherto unsuspected level of temporal coordination between the inputs and outputs of CE and BNST neurons, supporting the idea of shared functions.
PhysicalDescription
Extent
29 pages
InternetMediaType
application/pdf
Note (type = publications)
The original publication is available at: http://jn.physiology.org/cgi/content/full/100/6/3429
Name (type = personal)
NamePart (type = family)
Nagy
NamePart (type = given)
Frank Z.
Role
RoleTerm (authority = marcrt); (type = text)
author
Affiliation
Center for Molecular and Behavioral Neuroscience (CMBN), Rutgers University
Name (type = personal)
NamePart (type = family)
Paré
NamePart (type = given)
Denis
Role
RoleTerm (authority = marcrt); (type = text)
author
Affiliation
Center for Molecular and Behavioral Neuroscience (CMBN), Rutgers University
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Center for Molecular and Behavioral Neuroscience (CMBN)
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = inferred)
2008
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Extension
DescriptiveEvent
Type
Grant
Detail
R01 MH-073610
AssociatedEntity
Role
Sponsor
Name
National Institutes of Health (U.S.)
AssociatedEntity
Role
Originator
Name
Denis Paré
AssociatedObject
Type
Grant number
Name
R01 MH-073610
Detail
R01 MH-073610
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2008
AssociatedObject
Type
Journal
Relationship
Has part
Name
Journal of Neurophysiology
Identifier (type = volume and issue)
100(6)
Reference (type = digital)
http://dx.doi.org/10.1152/jn.90936.2008
Detail
3429-3436
RelatedItem (type = host)
TitleInfo
Title
Paré, Denis
Identifier (type = local)
rucore00000001075
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Rights

RightsDeclaration (AUTHORITY = FS); (ID = rulibRdec0004)
Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder (ID = CRH-1); (type = corporate)
Name
American Physiological Society
Role
Copyright holder
RightsEvent (ID = RE-1); (AUTHORITY = rulib)
Type
Permission or license
DateTime
2008-11-10
AssociatedEntity (ID = AE-1); (AUTHORITY = rulib)
Role
Depositor
Name
Denis Paré
AssociatedObject (ID = AO-1); (AUTHORITY = rulib)
Type
License
Name
Sole author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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Technical

ContentModel
Manuscript
MimeType (TYPE = file)
application/pdf
MimeType (TYPE = container)
application/x-tar
FileSize (UNIT = bytes)
2007040
Checksum (METHOD = SHA1)
26f98892c4431c00f18e54c7d0d28fcaa8783567
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