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The role of E-cadherin in the regulation of myelination in the peripheral nervous system
Descriptive
TypeOfResource
Text
TitleInfo
(ID = T-1)
Title
The role of E-cadherin in the regulation of myelination in the peripheral nervous system
Identifier
ETD_2972
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10002600001.ETD.000056098
Language
LanguageTerm
(authority = ISO639-2);
(type = code)
eng
Genre
(authority = marcgt)
theses
Subject
(ID = SBJ-1);
(authority = RUETD)
Topic
Biology
Subject
(ID = SBJ-2);
(authority = ETD-LCSH)
Topic
Myelination--Metabolism--Regulation
Subject
(ID = SBJ-3);
(authority = ETD-LCSH)
Topic
Cadherins
Abstract
In the mammalian nervous system, saltatory conduction is necessary for rapid velocities of action potentials down long axonal trunks. Myelination is the key to this near instantaneous transmission of signals. Oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system, are the cells that myelinate axons. While there is some understanding of how these cells concentrically wrap their plasma membranes around the axon to form this insulative layer, the precise induction mechanism is not clearly determined. A potential molecule involved in this process is E-cadherin, which has been previously identified to be localized to regions of compact myelin and various adhesion enriched areas. This study focuses on the role of E-cadherin, a member of the classical cadherin family of calcium dependent adhesion molecules, and its role in the initiation of myelination in the Schwann cells. Protein lysates of rat sciatic nerve demonstrate that expression of E-cadherin was shown to increase with development and that E-cadherin associated with ErbB2, a receptor tyrosine kinase known to function in Schwann cell development, promotes proliferation and myelination. Knockdown of E-cadherin has a negative effect on myelination in vitro, while ectopic expression of E-cadherin induces myelination. Additionally, upon perturbation of beta catenin binding to E-cadherin, enhanced proliferation and myelination was observed. This enhancement was found specifically in Superior Cervical Ganglion neurons (SCG), suggesting that beta-catenin coupling may also have an effect in myelination through an un-determined cadherin-catenin mechanism. These results suggest that cadherins have a critical role in the complex process of myelination.
PhysicalDescription
Form
(authority = gmd)
electronic resource
Extent
vii, 119 p. : ill.
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Darshan J. Desai
Name
(ID = NAME-1);
(type = personal)
NamePart
(type = family)
Desai
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(type = given)
Darshan
NamePart
(type = date)
1972-
Role
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(authority = RULIB)
author
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Darshan Desai
Name
(ID = NAME-2);
(type = personal)
NamePart
(type = family)
Kim
NamePart
(type = given)
Haesun A
Role
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(authority = RULIB)
chair
Affiliation
Advisory Committee
DisplayForm
Haesun A Kim
Name
(ID = NAME-3);
(type = personal)
NamePart
(type = family)
Friedman
NamePart
(type = given)
Wilma j
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
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Wilma j Friedman
Name
(ID = NAME-4);
(type = personal)
NamePart
(type = family)
Jonakait
NamePart
(type = given)
G. Miller
Role
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(authority = RULIB)
internal member
Affiliation
Advisory Committee
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G. Miller Jonakait
Name
(ID = NAME-5);
(type = personal)
NamePart
(type = family)
Melendez-Vasquez
NamePart
(type = given)
Carmen V
Role
RoleTerm
(authority = RULIB)
outside member
Affiliation
Advisory Committee
DisplayForm
Carmen V Melendez-Vasquez
Name
(ID = NAME-1);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME-2);
(type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm
(authority = RULIB)
school
OriginInfo
DateCreated
(qualifier = exact)
2010
DateOther
(qualifier = exact);
(type = degree)
2010-10
Place
PlaceTerm
(type = code)
xx
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier
(type = local)
rucore10002600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T30G3JZ7
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsHolder
(ID = PRH-1);
(type = personal)
Name
FamilyName
Desai
GivenName
Darshan
Role
Copyright Holder
RightsEvent
(ID = RE-1);
(AUTHORITY = rulib)
Type
Permission or license
DateTime
2010-09-30 16:38:29
AssociatedEntity
(ID = AE-1);
(AUTHORITY = rulib)
Role
Copyright holder
Name
Darshan Desai
Affiliation
Rutgers University. Graduate School - Newark
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(AUTHORITY = rulib)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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ETD
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(TYPE = file)
application/pdf
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application/x-tar
FileSize
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5079040
Checksum
(METHOD = SHA1)
5fe132f67da5f2db2b19e6e02655d51786ed2f86
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